number of access : ?
number of downloads : ?
ID 115785
Title Alternative
Urinary titin reflects muscle atrophy in critical ill patients
Author
Hara, Kanako Tokushima University
Mishima, Yuna Tokushima University
Machida, Kyoka Tokushima University
Keywords
Muscle atrophy
ICU-AW
urinary titin
biomarker
Content Type
Journal Article
Description
Skeletal muscle atrophy is a serious problem in critically ill patients. After intensive care unit (ICU)admission, muscle atrophy starts within 3 days and progressively worsens thereafter. We have previously reported that upper and lower limb muscle mass of critically ill patients decreased by 13%‐21% within 7 days of admission. Muscle atrophy in the ICU is associated with long-term functional impairment and weakness in ICU survivors. Although monitoring of muscle mass is important, there have been no reliable biomarkers associated with muscle atrophy in critically ill patients. In this study, we have focused on urinary titin, which is the biggest giant sarcomere protein and functions as a spring for muscle extension and viscoelasticity. We have clarified that urinary titin level reflected muscle breakdown correlated with limb muscle atrophy in non-surgical critically ill patients. The cumulative urinary titin level associated with the incidence of ICU-AW and ICU mortality. Our study indicates urinary titin can be the noble biomarker to evaluate the catabolism and muscle atrophy in critically ill patients.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
76
Issue
5-6
Start Page
267
End Page
272
Sort Key
267
Published Date
2020-12-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences
University Hospital