Yamada, Shinichiro Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Morine, Yuji Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ikemoto, Tetsuya Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Saito, Yu Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Teraoku, Hiroki Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Waki, Yuhei Tokushima University
Nakasu, Chiharu Tokushima University
Magnetic resonance imaging
Apparent diffusion coefficient
Background: We investigated the usefulness of apparent diffusion coefficients (ADC) from diffusion-weighted images (DWI) obtained using magnetic resonance imaging (MRI) for prognosis of early hepatocellular carcinoma (HCC): Barcelona Clinic Liver Cancer (BCLC) stage 0 and A.
Methods: We enrolled 102 patients who had undergone surgical resection for early HCC: BCLC stage 0 and A, and calculated their minimum ADC using DWI-MRI. We divided patients into ADCHigh (n = 72) and ADCLow (n = 30) groups, and compared clinicopathological factors between the two groups.
Results: The ADCLow group showed higher protein induced by vitamin K absence-II (PIVKA-II) levels (p = 0.02) compared with the ADCHigh group. In overall survival, the ADCLow group showed significantly worse prognosis than the ADCHigh group (p < 0.01). Univariate analysis identified multiple tumors, infiltrative growth, high PIVKA-II, and low ADC value as prognostic factors. Multivariate analysis identified infiltrative growth and low ADC value as an independent prognostic factor.
Conclusion: ADC values can be used to estimate the prognosis of early HCC.
BioMed Central|Springer Nature
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