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ID 113940
Author
Tanaka, Kazue Tokushima University
Keywords
lysoglycerophospholipid
Horner-Wadsworth-Emmons reaction
fluorine
lysophosphatidic acid
lysophosphatidylethanolamine
lysophosphatidylcholine
Content Type
Journal Article
Description
This article describes an efficient method of synthesizing fluorine-containing analogues of 1-lysoglycerophospholipids (1-LPLs) by introducing a palmitoyl moiety starting from bis(2,2,2-trifluoroethyl)phosphonoacetate (Still-Gennari reagent). Our method effectively employs Horner-Wadsworth-Emmons reagents as masked 1-LPL derivatives to prepare a series of analogues of 1-lysophosphatidic acid (1-LPA), 1-lysophosphatidylethanolamine (1-LPE), and 1-lysophosphatidylcholine (1-LPC).
Journal Title
Synthesis
ISSN
00397881
1437210X
NCID
AA00855740
Publisher
Georg Thieme Verlag Stuttgart
Volume
49
Issue
16
Start Page
3654
End Page
3661
Published Date
2017-05-18
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Pharmaceutical Sciences
Technical Support Department