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ID 118348
Title Alternative
Polymethoxyflavonids and T helper 17 cells
Author
Hirabayashi, Yuwa Tokushima University
Anzaki, Chieri Tokushima University
Shuto, Emi Okayama Prefectural University KAKEN Search Researchers
Nii, Yoshitaka Tokushima Prefectural Industrial Technology Center
Keywords
polymethoxyflavonoids
nobiletin
sudachitin
T helper 17 cell
IL-17A
Content Type
Journal Article
Description
We examined the effects of polymethoxyflavonoids (PMFs) on T helper (Th) 17 cell differentiation in vitro and in vivo. Five different PMFs including nobiletin (NOB), sudachitin (SUD), demethoxysudachitin, heptamethoxyflavone and natsudaidain were used for the in vitro study, and effects of those flavonoids on Th17 responses were investigated. NOB and heptamethoxyflavone significantly suppressed the proliferation response, but SUD, demethoxysudachitin and natsudaidain did not suppress the proliferation response. All of the five flavonoids decreased IL-17A production. Mice with experimentally induced autoimmune encephalomyelitis were used as an in vivo Th17 differentiation model. We focused on two flavonoids, NOB and SUD, and examined the effects of those flavonoids. NOB significantly suppressed Th17 cell proliferation and cytokine responses, but SUD only decreased proliferation responses. The results suggest that the suppressive effect of NOB on Th17 response in vivo is stronger than that of SUD.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
70
Issue
1-2
Start Page
166
End Page
170
Sort Key
166
Published Date
2023-02
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences