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ID 115051
Author
Okamoto, Shiki National Institute of Natural Sciences|SOKENDAI|University of the Ryukyus
Sato, Tatsuya National Institute of Natural Sciences|SOKENDAI
Tateyama, Michihiro SOKENDAI|National Institute of Natural Sciences
Kageyama, Haruaki Kiryu University
Maejima, Yuko Jichi Medical University|Fukushima Medical University
Nakata, Masanori Jichi Medical University
Hirako, Satoshi University of Human Arts and Sciences
Matsuo, Takashi National Institute of Natural Sciences|University of Miyazaki
Kyaw, Sanda National Institute of Natural Sciences|University of Medicine 1
Toda, Chitoku National Institute of Natural Sciences|Hokkaido University
Sedbazar, Udval Jichi Medical University
Saito, Kumiko National Institute of Natural Sciences
Asgar, Nur Farehan National Institute of Natural Sciences|SOKENDAI
Zhang, Boyang Jichi Medical University
Yokota, Shigefumi National Institute of Natural Sciences|Kyoto Medical Center
Kobayashi, Kenta SOKENDAI|National Institute of Natural Sciences
Foufelle, Fabienne Sorbonne Université|INSERM|Université Paris Descartes
Ferré, Pascal Sorbonne Université|INSERM|Université Paris Descartes
Nakazato, Masamitsu University of Miyazaki
Masuzaki, Hiroaki University of the Ryukyus
Shioda, Seiji Hoshi University School of Pharmacy and Pharmaceutical Sciences
Yada, Toshihiko Jichi Medical University
Kahn, Barbara B. Beth Israel Deaconess Medical Center and Harvard Medical School
Minokoshi, Yasuhiko National Institute of Natural Sciences|SOKENDAI
Content Type
Journal Article
Description
Food selection is essential for metabolic homeostasis and is influenced by nutritional state, food palatability, and social factors such as stress. However, the mechanism responsible for selection between a high-carbohydrate diet (HCD) and a high-fat diet (HFD) remains unknown. Here, we show that activation of a subset of corticotropin-releasing hormone (CRH)-positive neurons in the rostral region of the paraventricular hypothalamus (PVH) induces selection of an HCD over an HFD in mice during refeeding after fasting, resulting in a rapid recovery from the change in ketone metabolism. These neurons manifest activation of AMP-activated protein kinase (AMPK) during food deprivation, and this activation is necessary and sufficient for selection of an HCD over an HFD. Furthermore, this effect is mediated by carnitine palmitoyltransferase 1c (CPT1c). Thus, our results identify the specific neurons and intracellular signaling pathway responsible for regulation of the complex behavior of selection between an HCD and an HFD.
Journal Title
Cell Reports
ISSN
22111247
Publisher
Elsevier
Volume
22
Issue
3
Start Page
706
End Page
721
Published Date
2018-01-16
Rights
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences