Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat

Okamoto, Shiki; Sato, Tatsuya; Tateyama, Michihiro; Kageyama, Haruaki; Maejima, Yuko; Nakata, Masanori; Hirako, Satoshi; Matsuo, Takashi; Kyaw, Sanda; Shiuchi, Tetsuya; Toda, Chitoku; Sedbazar, Udval; Saito, Kumiko; Asgar, Nur Farehan; Zhang, Boyang; Yokota, Shigefumi; Kobayashi, Kenta; Foufelle, Fabienne; Ferré, Pascal; Nakazato, Masamitsu; Masuzaki, Hiroaki; Shioda, Seiji; Yada, Toshihiko; Kahn, Barbara B.; Minokoshi, Yasuhiko

doi:10.1016/j.celrep.2017.11.102

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ID	115051
Author	Okamoto, Shiki National Institute of Natural Sciences\|SOKENDAI\|University of the Ryukyus Sato, Tatsuya National Institute of Natural Sciences\|SOKENDAI Tateyama, Michihiro SOKENDAI\|National Institute of Natural Sciences Kageyama, Haruaki Kiryu University Maejima, Yuko Jichi Medical University\|Fukushima Medical University Nakata, Masanori Jichi Medical University Hirako, Satoshi University of Human Arts and Sciences Matsuo, Takashi National Institute of Natural Sciences\|University of Miyazaki Kyaw, Sanda National Institute of Natural Sciences\|University of Medicine 1 Shiuchi, Tetsuya National Institute of Natural Sciences\|Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers Toda, Chitoku National Institute of Natural Sciences\|Hokkaido University Sedbazar, Udval Jichi Medical University Saito, Kumiko National Institute of Natural Sciences Asgar, Nur Farehan National Institute of Natural Sciences\|SOKENDAI Zhang, Boyang Jichi Medical University Yokota, Shigefumi National Institute of Natural Sciences\|Kyoto Medical Center Kobayashi, Kenta SOKENDAI\|National Institute of Natural Sciences Foufelle, Fabienne Sorbonne Université\|INSERM\|Université Paris Descartes Ferré, Pascal Sorbonne Université\|INSERM\|Université Paris Descartes Nakazato, Masamitsu University of Miyazaki Masuzaki, Hiroaki University of the Ryukyus Shioda, Seiji Hoshi University School of Pharmacy and Pharmaceutical Sciences Yada, Toshihiko Jichi Medical University Kahn, Barbara B. Beth Israel Deaconess Medical Center and Harvard Medical School Minokoshi, Yasuhiko National Institute of Natural Sciences\|SOKENDAI
Content Type	Journal Article
Description	Food selection is essential for metabolic homeostasis and is influenced by nutritional state, food palatability, and social factors such as stress. However, the mechanism responsible for selection between a high-carbohydrate diet (HCD) and a high-fat diet (HFD) remains unknown. Here, we show that activation of a subset of corticotropin-releasing hormone (CRH)-positive neurons in the rostral region of the paraventricular hypothalamus (PVH) induces selection of an HCD over an HFD in mice during refeeding after fasting, resulting in a rapid recovery from the change in ketone metabolism. These neurons manifest activation of AMP-activated protein kinase (AMPK) during food deprivation, and this activation is necessary and sufficient for selection of an HCD over an HFD. Furthermore, this effect is mediated by carnitine palmitoyltransferase 1c (CPT1c). Thus, our results identify the specific neurons and intracellular signaling pathway responsible for regulation of the complex behavior of selection between an HCD and an HFD.
Journal Title	Cell Reports
ISSN	22111247
Publisher	Elsevier
Volume	22
Issue	3
Start Page	706
End Page	721
Published Date	2018-01-16
Rights	This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID	343502
DOI (Published Version)	10.1016/j.celrep.2017.11.102
URL ( Publisher's Version )	https://doi.org/10.1016/j.celrep.2017.11.102
FullText File	celrep_22_3_706.pdf 6.18 MB
language	eng
TextVersion	Publisher
departments	Medical Sciences