| ID | 110839 |
| Author |
Honda, Junko
Department of Oncological and Regenerative Surgery, Institute of Health Biosciences Department of Surgery, The University of Tokushima Graduate School
Sasa, Mitsunori
Department of Surgery, Tokushima Breast Care Clinic
Moriya, Takuya
Department of Pathology 2, Kawasaki Medical School
Bando, Yoshimi
Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School
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Hirose, Toshiyuki
Department of Surgery, National Higashi Tokushima Hospital
Takahashi, Masako
Department of Surgery, Tokushima Breast Care Clinic
Nagao, Taeko
Department of Oncological and Regenerative Surgery, Institute of Health Biosciences Department of Surgery, The University of Tokushima Graduate School
Tangoku, Akira
Department of Oncological and Regenerative Surgery, Institute of Health Biosciences Department of Surgery, The University of Tokushima Graduate School
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|
| Keywords | breast cancer
capecitabine
dihydropyrimidine dehydrogenase
predictive factor
thymidine phosphorylase
|
| Content Type |
Journal Article
|
| Description | Capecitabine monotherapy was administered for 25 patients with advanced or recurrent breast cancer, and the clinical therapeutic efficacy and its relationship to expression of 5-fluorouracil-related enzymes (i.e., thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD)) were investigated. The expressions of TP, TS and DPD were determined by immunohistochemical staining techniques and rated using a scoring system of 1～4. The expression score for TP/DPD showed a statistically significant correlation with the clinical response, whereas the expression score for TP/TS also showed a correlation but it was not statistically significant. The number of patients was small, but the results revealed the potential of application of the TP/DPD expression score as a factor for predicting the efficacy of the drug in individual patients.
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| Journal Title |
The journal of medical investigation : JMI
|
| ISSN | 13431420
|
| NCID | AA11166929
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| Volume | 55
|
| Issue | 1-2
|
| Start Page | 54
|
| End Page | 60
|
| Sort Key | 54
|
| Published Date | 2008-02
|
| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
|
| TextVersion |
Publisher
|
| departments |
University Hospital
Medical Sciences
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