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ID 119342
Title Alternative
肺腺癌においてdipeptidyl peptidase‑like 6 (DPP-6)遺伝子のDNAメチル化は予後の指標となる
ABERRANT METHYLATION OF DPP6 IN LUNG ADENOCARCINOMA
Author
Munkhjargal, Batkhishig Tokushima University
Soejima, Shiho Tokushima University
Tegshee, Bilguun Case Western Reserve University
Takai, Chikako Tokushima University
Keywords
lung cancer
DPP6
DNA
methylation
mRNA expression
prognosis
Content Type
Thesis or Dissertation
Description
We previously performed the genome‑wide screening of aberrantly methylated CpG islands (CGIs) using the paired tumorous and non‑tumorous tissues of 12 lung adenocarcinomas (LADC). In comparisons with paired normal lung tissues, dipeptidyl peptidase‑like 6 (DPP6) has been identified as the most significantly hypermethylated CGI in LADC. DPP6 is a protein that modulates A‑type potassium channels in the somatodendritic compartments of neurons, which play a role in synaptic plasticity. Previous studies have showed that DPP6 is downregulated in cancers, such as acute myeloid leukemia and melanoma, but upregulated in colon cancer, which is attributed to hyper‑ and hypomethylation, respectively. The present study investigated the methylation and expression levels of DPP6 and its prognostic value in patients with LADC. The DNA methylation and mRNA expression levels of DPP6 in surgically resected LADC tissues were examined by bisulfite pyrosequencing and reverse transcription‑quantitative PCR, respectively. The DNA methylation and mRNA expression levels of DPP6 were both significantly higher in LADC tissues compared with in normal lung tissues (n=25; P<0.0001). Overall and disease‑free survival rates were significantly higher in LADC with high mRNA expression levels compared with those with low levels. In conclusion, epigenetic alterations in DPP6 were significantly higher in LADC tissues compared with in normal lung tissues, which may contribute to the malignant features and worse prognosis of these patients.
Journal Title
Oncology Letters
ISSN
17921074
17921082
Publisher
Spandidos Publications
Volume
25
Issue
5
Start Page
206
Published Date
2023-04-05
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Batkhishig Munkhjargalの学位論文として提出され,学位審査・授与の対象となっている。
Rights
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License.( https://creativecommons.org/licenses/by-nc-nd/4.0/ )
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3805号
Diploma Number
甲保第68号
Granted Date
2024-03-22
Degree Name
Doctor of Health Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital