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ID 115258
Title Alternative
Endolymphatic Hydrops After Sac Surgery
Author
Ito, Taeko Nara Medical University
Inui, Hiroshi Nara Medical University|Inui ENT Clinic
Miyasaka, Toshiteru Nara Medical University
Shiozaki, Tomoyuki Nara Medical University
Matsuyama, Shohei Nara Medical University
Yamanaka, Toshiaki Nara Medical University
Kichikawa, Kimihiko Nara Medical University
Kitahara, Tadashi Nara Medical University
Keywords
endolymphatic hydrops
Meniere’s disease
surgery
MRI
endolymphatic sac
Content Type
Journal Article
Description
Meniere’s disease is a common disease, that presents with recurrent vertigo and cochlear symptoms. The pathology of Meniere’s disease was first reported to involve endolymphatic hydrops in 1938. The endolymphatic sac is thought to have a role to keep the hydrostatic pressure and endolymph homeostasis for the inner ear. As a surgery for intractable Meniere’s disease, endolymphatic sac drainage with intraendolymphatic sac application of large doses of steroids is performed to control the endolymphatic hydrops and preserve or improve inner ear function. In the present study, to observe the effect of this surgery, we calculated the endolymphatic space size using 3-Teslamagnetic resonance imaging (MRI) 4 h after intravenous injection of gadolinium enhancement at two time points: just before surgery and 2 years after. To reveal the condition of the endolymphatic space, we constructed three-dimensional MR images semi-automatically and fused the three-dimensional images of the total fluid space of inner ear and the endolymphatic space. After fusing the images, we calculated the volume of the total fluid space and endolymphatic space. Two years after surgery, 16 of 20 patients (80.0%) showed relief from vertigo/dizziness and reductions in the ratio of the volume of the endolymphatic size to the total fluid space of inner ear. Endolymphatic sac drainage with intraendolymphatic sac application of large doses of steroids could control vertigo/dizziness and decrease the endolymphatic hydrops. These results indicate that endolymphatic sac drainage is a good treatment option for patients with intractable Meniere’s disease. In addition, volumetric measurement of inner ear volume could be useful for confirming the effect of treatments on Meniere’s disease.
Journal Title
Frontiers in Neurology
ISSN
16642295
Publisher
Frontiers Media S.A.
Volume
10
Start Page
46
Published Date
2019-02-04
Rights
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) ( https://creativecommons.org/licenses/by/4.0/ ). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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language
eng
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departments
Medical Sciences