Preoperative CT-guided ICG injection locating SPNs
Li, Xukai Guangzhou Medical University|Guangdong Second Provincial General Hospital
Xu, Ke Guangzhou Medical University
Cen, Renli Guangzhou Medical University
Deng, Jinghui Guangzhou Medical University
Hao, Zhexue Guangzhou Medical University
Liu, Jun Guangzhou Medical University
Takizawa, Hiromitsu Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ng, Calvin S. H. The Chinese University of Hong Kong
Marulli, Giuseppe University Hospital of Bari
Kim, Min P. Houston Methodist Hospital
Cui, Fei Guangzhou Medical University
He, Jianxing Guangzhou Medical University
Computed tomography (CT)
indocyanine green (ICG)
video-assisted thoracoscopic surgery (VATS)
Background: Localization of small pulmonary nodules (SPNs) is challenging in minimally invasive pulmonary resection, and it is unknown whether computer tomography (CT) guided by indocyanine green (ICG) can provide accurate localization with minimal complications.
Methods: We performed a retrospective study of patients who underwent thoracoscopic resection of pulmonary nodules after CT-guided preoperative localization with ICG from May 2019 to May 2020. Demographics, procedural data, postoperative complications, and pathologic information, were collected, and an analysis of the accuracy and complications after surgery was conducted.
Results: In 471 patients, there was a total of 512 peripheral pulmonary nodules that were ≤2 cm in size. The average time for CT-guided percutaneous ICG injection for localization was 18 minutes, and 98.4% (504/512) of the nodules were successfully localized. The average size of the nodules was 9.1 mm, and the average depth from the pleural surface was 8.9 mm. Overall, 5.9% (28/471) of the patients had asymptomatic pneumothorax after localization, but none needed a tube thoracostomy. All the nodules were resected using video-assisted thoracoscopy technique.
Conclusions: Preoperative CT-guided transthoracic ICG injection is safe and feasible for localization of small lung nodules for minimally invasive pulmonary resection. This technique should be considered for preoperative CT-guided localization of small lung nodules.
Translational Lung Cancer Research
AME Publishing Company
This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the noncommercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
|DOI (Published Version)|
|URL ( Publisher's Version )|
tlcr_10_5_2229.pdf 772 KB