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ID 113365
Title Alternative
Senescence-accelerated mouse-prone 8 (SAMP8)マウスにおけるオリーブオイル摂取の老化への効果
Effects of olive oil in SAMP8 mice
Author
Bando, Masahiro Tokushima University
Masumoto, Saeko Tokushima University
Keywords
Mediterranean diet
olive oil
MUFA
SAMP8
aging
passive avoidance
Content Type
Thesis or Dissertation
Description
Background : Mediterranean diets have been linked to a reduced risk of cancer, vascular illnesses, Parkinson’s and Alzheimer’s disease. Olive oil is the primary fat source in the Mediterranean diet ; however, only a few studies have investigated the effect of olive oil on aging. In the present study, we aimed to determine whether consumption of olive oil significantly influences aging and memory in senescence-accelerated mouse-prone 8 (SAMP8). Methods : SAMP8 and senescence-accelerated mouse resistant 1 (SAMR1) mice were fed either 7% soy oil or 1% olive oil and 6% soy oil during a six-month study period. Reduction in memory in passive avoidance learning was examined after two months from the initiation of the experiment. Results : The weight of organs including the liver, kidney, spleen, and fat tissue changed significantly and memory performance was reduced in SAMP8 than in SAMR1 mice. There were no significant differences in SAMP8 and SAMR1 mice; however, blood triglyceride level decreased significantly in SAMP8 mice fed on olive oil. Conclusions : These results suggest that consuming olive oil may not have a protective role in aging and memory recall, but beneficial effects may be related to improvement in lipid metabolism.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA12022913
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
66
Issue
3-4
Start Page
241
End Page
247
Sort Key
241
Published Date
2019-08
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Masahiro Bandoの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3276号
Diploma Number
甲栄第265号
Granted Date
2019-03-22
Degree Name
Doctor of Nutritional Science
Grantor
Tokushima University
departments
Medical Sciences