ID | 114401 |
Author |
Obata, Fumiaki
Tokushima University
Miki, Hirokazu
Tokushima University
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Nishimura, Kenji
Tokushima University
Kishi, Fumi
Tokushima University
Abe, Masahiro
Tokushima University
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Doi, Toshio
Tokushima University
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Keywords | Light Chain Proximal Tubulopathy (LCPT)
IgD λ myeloma
paraprotein related kidney disease
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Content Type |
Journal Article
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Description | Light Chain Proximal Tubulopathy (LCPT) is a rare form of paraprotein-related kidney disease in which monoclonal free light chains damage the proximal renal tubular epithelial cells. We herein report the case of a 78-year-old woman who presented with anemia and kidney dysfunction. Serum and urine protein electrophoresis analyses revealed a monoclonal IgD and λ free light chains. Proximal tubular injury and the accumulation of λ light chains were found by kidney biopsy. Electron microscopy revealed no organized structure suggestive of crystals. LCPT was caused by IgD lambda myeloma and bortezomib and dexamethasone therapy led to very good partial response (VGPR) without a worsening of the kidney function.
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Journal Title |
Internal Medicine
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ISSN | 13497235
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Publisher | The Japanese Society of Internal Medicine
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Volume | 57
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Issue | 24
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Start Page | 3597
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End Page | 3602
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Published Date | 2018-12-15
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Rights | The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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DOI (Published Version) | |
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language |
eng
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TextVersion |
Publisher
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departments |
University Hospital
Medical Sciences
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