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ID 118250
Title Alternative
血管内皮機能は心血管リスクを有する女性および非喫煙男性のeGFR slopeと関連している : 腎予後に対するFMDの予測能に関するパイロット研究
FMD and eGFR Slope in Males and Females
Author
Masuda, Shiho Tokushima University
Mitsui, Yukari Tokushima University
Otoda, Toshiki Tokushima University
Keywords
Sex difference
FMD
baPWV
eGFR slope
Cigarette smoking
Content Type
Thesis or Dissertation
Description
Aims: It is known that there are sex differences in vascular endothelial function and the development of chronic kidney diseases; however, it remains unclear whether sex differences influence the association between vascular endothelial function and renal prognosis.
Methods: To clarify the relationship between vascular endothelial function and longitudinal eGFR changes in male and female patients with cardiovascular risk factors, we retrospectively evaluated 341 patients (176 males and 165 females) with cardiovascular risk factors in whom vascular function was assessed by flow-mediated dilation (FMD) and brachial ankle pulse wave velocity (baPWV) and in whom 24-month longitudinal eGFR values were recorded after the vascular function examinations. Associations of values of FMD and baPWV with values of eGFR slope were statistically analyzed.
Results: Simple regression analysis showed that the value of FMD was positively associated with eGFR slope in females (p=0.001) and non-smoking males (p=0.033) but not in smoking males. Multiple regression analysis showed that the value of FMD remains a positive contributor for eGFR slope in females (p=0.001) and nonsmoking males (p=0.045) but not in smoking males. In contrast, values of baPWV had no significant association with eGFR slope regardless of sex and cigarette smoking.
Conclusions: In individuals with cardiovascular risk factors, evaluation of vascular endothelial function enables prediction of renal prognosis in females and non-smoking males.
Journal Title
Journal of Atherosclerosis and Thrombosis
ISSN
18803873
13403478
Publisher
Japan Atherosclerosis Society
Volume
30
Issue
11
Start Page
1727
End Page
1741
Published Date
2023
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Shiho Masudaの学位論文として提出され,学位審査・授与の対象となっている。
Rights
This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.( https://creativecommons.org/licenses/by-nc-sa/4.0/deed.ja )
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3755号
Diploma Number
甲医第1580号
Granted Date
2023-09-28
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital
Institute of Advanced Medical Sciences