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ID 115523
Author
Sato, Aya Tokushima University
Shono, Kenji Tokushima University
Kitazato, Keiko Tokushima University
Matsuzaki, Kazuhito Tokushima University
Sumi, Akiko Tokushima University
Saya, Hideyuki Keio University
Sampetrean, Oltea Keio University
Keywords
COX-2
Low-grade glioma
Akt
Survivin
ID3
Content Type
Journal Article
Description
Approximately half of surgically-treated patients with low-grade-glioma (LGG) suffer recurrence or metastasis. Currently there is no effective drug treatment. While the selective COX-2 inhibitor celecoxib showed anti-neoplastic activity against several malignant tumors, its effects against LGG remain to be elucidated. Ours is the first report that the expression level of COX-2 in brain tissue samples from patients with LGG and in LGG cell lines is higher than in the non-neoplastic region and in normal brain cells. We found that celecoxib attenuated LGG cell proliferation in a dose-dependent manner. It inhibited the generation of prostaglandin E2 and induced apoptosis and cell-cycle arrest. We also show that celecoxib hampered the activation of the Akt/survivin- and the Akt/ID3 pathway in LGGs. These findings suggest that celecoxib may have a promising therapeutic potential and that the early treatment of LGG patients with the drug may be beneficial.
Journal Title
Journal of Neuro-Oncology
ISSN
0167594X
15737373
NCID
AA10633712
Publisher
Springer Nature
Volume
132
Issue
2
Start Page
231
End Page
238
Published Date
2017-03-10
Remark
著者英表記誤記あり (誤)Shinji Nagahirao →(正)Shinji Nagahiro
Rights
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
University Hospital