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ID 113683
Author
Sato, Hideo Tokushima University
Nagano, Shuji Tokushima University
Imagawa, Hiroshi Tokushima Bunri University
Keywords
total synthesis
natural product
dihydropyran
Content Type
Journal Article
Description
Asymmetric total syntheses of dihydropyran containing natural products, (+)-eurotiumide F and (+)-eurotiumide G have been described. These total syntheses revealed the absolute configuration of eurotiumide F and G, and confirmed the reported structure of eurotiumide F and revised the reported structure of eurotiumide G. Highlight of these syntheses is thermal rearrangement with 4-methoxyisochroman-1-one derivative having propargyl ether on phenolic ether under thermal condition to construct dihydropyran ring. X-Ray crystallographic analysis of (+)-eurotiumide G clarified the stereochemistry at the C1-position.
Journal Title
Chemical and Pharmaceutical Bulletin
ISSN
00092363
13475223
NCID
AA00602100
Publisher
The Pharmaceutical Society of Japan
Volume
67
Issue
9
Start Page
953
End Page
958
Published Date
2019-09-01
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Pharmaceutical Sciences