number of access : ?
number of downloads : ?
ID 114339
Title Alternative
CSC with and without steroids
Author
Araki, Takashi Hyogo College of Medicine|JCREST (Japan Clinical Retina Study) group
Ishikawa, Hiroto Hyogo College of Medicine|JCREST (Japan Clinical Retina Study) group
Iwahashi, Chiharu JCREST (Japan Clinical Retina Study) group|Sumitomo Hospital
Niki, Masanori JCREST (Japan Clinical Retina Study) group|Tokushima University Tokushima University Educator and Researcher Directory
Mitamura, Yoshinori JCREST (Japan Clinical Retina Study) group|Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Sugimoto, Masahiko JCREST (Japan Clinical Retina Study) group|Mie University
Kondo, Mineo JCREST (Japan Clinical Retina Study) group|Mie University
Kinoshita, Takamasa JCREST (Japan Clinical Retina Study) group|Sapporo City General Hospital
Nishi, Tomo JCREST (Japan Clinical Retina Study) group|Nara Medical University
Ueda, Tetsuo JCREST (Japan Clinical Retina Study) group|Nara Medical University
Kato, Aki JCREST (Japan Clinical Retina Study) group|Nagoya City University
Yasukawa, Tsutomu JCREST (Japan Clinical Retina Study) group|Nagoya City University
Takamura, Yoshihiro JCREST (Japan Clinical Retina Study) group|Fukui University
Gomi, Fumi Hyogo College of Medicine|JCREST (Japan Clinical Retina Study) group
Content Type
Journal Article
Description
We investigated the rates of the use of steroids in Japanese central serous chorioretinopathy (CSC) cases and differences in the characteristics of CSC with and without steroids. A total of 538 eyes of 477 patients diagnosed with CSC, with 3 months or more of follow-up between April 2013 and June 2017 at 8 institutions. Patients with CSC with more than 3 months of follow-up were identified by OCT and fluorescein angiography at 8 institutions. Data collected included patient demographics, history of corticosteroid medication and smoking, spherical errors, findings of angiography, subfoveal choroidal thickness, and changes through the follow-up period. Differences in these findings were analyzed in cases with and without corticosteroid treatment. Among the 477 patients (344 men,133 women), 74 (15.5%) (39 men, 35 women) underwent current or prior steroid treatment. Cases with steroids were higher age (p = 0.0403) and showed no male prevalence, more bilateral involvement (p < 0.0001), and the affected eyes had multiple pigment epithelial detachment (p <0.0001), more fluorescein leakage sites (p < 0.0001), greater choroidal thickness (p = 0.0287) and a higher recurrence rate (p = 0.0412). Steroids can cause severer CSC through an effect on choroidal vessels and an impairment of retinal pigment epithelium.
Journal Title
PLOS ONE
ISSN
19326203
Publisher
PLOS
Volume
14
Issue
2
Start Page
e0213110
Published Date
2019-02-28
Rights
© 2019 Araki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences
University Hospital