Matsumoto, Yuki Tokushima University Tokushima University Educator and Researcher Directory
Harada, Masafumi Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kanazawa, Yuki Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Taniguchi, Yo FUJIFILM Healthcare Corporation
Ono, Masaharu FUJIFILM Healthcare Corporation
Bito, Yoshitaka FUJIFILM Healthcare Corporation
Thesis or Dissertation
In clinical magnetic resonance imaging, gadolinium-based contrast agents are commonly used for detecting brain tumors and evaluating the extent of malignancy. We present a new method to evaluate relaxivity (r1) and contrast agent concentration separately in contrast-enhanced lesions using quantitative parameter mapping (QPM). Furthermore, we also aimed to estimate the extracellular pH (pHe) of tumor lesions. We demonstrated that it is possible to evaluate pathophysiological tumor changes due to therapeutic efficacy by measuring r1 in contrast-enhanced lesions. In this study, the primary brain tumor group showed significantly higher r1 values than other brain disease groups (P < 0.001). Moreover, mean pHe value showed a trend for tumor malignancy having a lower pHe value and primary brain tumor having a significantly lower pHe than other brain diseases (P < 0.001). Our results might suggest that QPM can separately quantify r1 and CA concentration in brain tumors and that pHe brain tumor mapping could serve as a tumor biomarker. In conclusion, our method has potential clinical applications for assessing the treatment effects.
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|DOI (Published Version)|
|URL ( Publisher's Version )|
k3599_abstract.pdf 121 KB
k3599_review.pdf 117 KB
k3599_fulltext.pdf 787 KB
|MEXT report number||
Doctor of Medical Science