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ID 118012
Author
Yagi, Mai Tokushima University|Tokushima Prefectural Central Hospital
Muraki, Sho Tokushima University|Shikoku Medical Center for Children and Adults
Fujimoto, Shota Tokushima University
Keywords
gastric cancer
pulmonary tumor thrombotic microangiopathy (PTTM)
cardiac catheterization
vascular endothelial growth factor (VEGF)
Content Type
Journal Article
Description
A 66-year-old Japanese man receiving systemic chemotherapy for advanced gastric cancer presented with exertional dyspnea. D-dimer was elevated in the blood. Echocardiography revealed pulmonary hypertension, and a ventilation-perfusion scan indicated decreased perfusion in the bilateral lungs. Cardiac catheterization showed no evidence of pulmonary artery embolization and revealed cytologically confirmed adenocarcinoma. Thus, pulmonary tumor thrombotic microangiopathy (PTTM) was diagnosed. The patient died of respiratory failure on the 17th hospitalization day despite systemic chemotherapy. Retrospective serological testing revealed increased vascular endothelial growth factor in the pulmonary artery blood. This is a rare case with antemortem cytologically proven PTTM mediated by VEGF.
Journal Title
Internal Medicine
ISSN
13497235
Publisher
The Japanese Society of Internal Medicine
Volume
61
Issue
10
Start Page
1491
End Page
1495
Published Date
2022-05-15
Rights
The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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language
eng
TextVersion
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departments
University Hospital
Medical Sciences