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ID 114682
Title Alternative
マイクロファイバーを用いた多孔質炭酸アパタイト顆粒の開発とウサギ頭蓋骨における組織学的評価
Author
Tsuru, Kanji Fukuoka Dental College
Ishikawa, Kunio Kyushu University
Keywords
bone formation
bone substitute
carbonate apatite
hydroxyapatite
optimal pore size
Content Type
Thesis or Dissertation
Description
Carbonate apatite (CO3Ap) granules are known to show good osteoconductivity and replaced to new bone. On the other hand, it is well known that a porous structure allows bone tissue to penetrate its pores, and the optimal pore size for bone ingrowth is dependent on the composition and structure of the scaffold material. Therefore, the aim of this study was to fabricate various porous CO3Ap granules through a two-step dissolution-precipitation reaction using CaSO4 as a precursor and 30-, 50-, 120-, and 205-μm diameter microfibers as porogen and to find the optimal pore size of CO3Ap. Porous CO3Ap granules were successfully fabricated with pore size 8.2-18.7% smaller than the size of the original fiber porogen. Two weeks after the reconstruction of rabbit calvarial bone defects using porous CO3Ap granules, the largest amount of mature bone was seen to be formed inside the pores of CO3Ap (120) [porous CO3Ap granules made using 120-μm microfiber] followed by CO3Ap (50) and CO3Ap (30). At 4 and 8 weeks, no statistically significant difference was observed based on the pore size, even though largest amount of mature bone was formed in case of CO3Ap (120). It is concluded, therefore, that the optimal pore size of the CO3Ap is that of CO3Ap (120), which is 85 μm.
Journal Title
Journal of Biomedical Materials Research Part A
ISSN
15493296
15524965
NCID
AA11881516
Publisher
Wiley
Volume
108
Issue
3
Start Page
709
End Page
721
Published Date
2019-11-22
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Kazuya Akitaの学位論文として提出され,学位審査・授与の対象となっている。
This is the peer reviewed version of the following article: Kazuya Akita, Naoyuki Fukuda, Kumiko Kamada, Keiko Kudoh, Naito Kurio, Kanji Tsuru, Kunio Ishikawa, Youji Miyamoto. Fabrication of porous carbonate apatite granules using microfiber and its histological evaluations in rabbit calvarial bone defects. J Biomed Mater Res. 2020; 108A: 709– 721., which has been published in final form at https://doi.org/10.1002/jbm.a.36850. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3375号
Diploma Number
甲口第454号
Granted Date
2020-03-23
Degree Name
Doctor of Dental Science
Grantor
Tokushima University
departments
Oral Sciences
University Hospital