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ID 117171
Title Alternative
A case of myasthenia gravis induced by nivolumab
ニボルマブによる重症筋無力症
Author
Morimoto, Masami Shikoku Central Hospital of the Mutual aid Association of Public School teachers
Ishikawa, Masashi Shikoku Central Hospital of the Mutual aid Association of Public School teachers
Tashiro, Yoshihiko Shikoku Central Hospital of the Mutual aid Association of Public School teachers
Takechi, Hirokazu Shikoku Central Hospital of the Mutual aid Association of Public School teachers KAKEN Search Researchers
Matsuyama, Kazuo Shikoku Central Hospital of the Mutual aid Association of Public School teachers
Miyauchi, Takayuki Shikoku Central Hospital of the Mutual aid Association of Public School teachers
Kitagawa, Tetsuya Shikoku Central Hospital of the Mutual aid Association of Public School teachers Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
nivolumab
immune-related adverse events
myasthenia gravis
Content Type
Journal Article
Description
A 70s female suffering from recurrent gastric cancer presented with ptosis, dysphagia and lower limb and neck muscles weakness with elevation of serum CK levels after second treatment with the immune checkpoint inhibitor nivolumab. The symptoms suggested myasthenia gravis (MG), although anti-acetylcholine receptor antibody and muscle-specific receptor tyrosine kinase antibody were negative. Steroid treatment quickly normalized CK levels and relieved MG symptoms. Nivolumab-induced MG can rapidly become severe and potentially fatal, and a prompt and accurate response is desirable.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
78
Issue
1-2
Start Page
65
End Page
70
Sort Key
65
Published Date
2022-04-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences
University Hospital