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ID 114347
Title Alternative
IOP elevation after STTA
Author
Maeda, Yuki J-CREST (Japan Clinical REtina STudy group)|Hyogo College of Medicine
Ishikawa, Hiroto J-CREST (Japan Clinical REtina STudy group)|Hyogo College of Medicine
Nishikawa, Hiroki Hyogo College of Medicine
Shimizu, Miho J-CREST (Japan Clinical REtina STudy group)|Sapporo City General Hospital
Kinoshita, Takamasa J-CREST (Japan Clinical REtina STudy group)|Sapporo City General Hospital
Ogihara, Rie J-CREST (Japan Clinical REtina STudy group)|Tokyo Women’s Medical University
Kitano, Shigehiko J-CREST (Japan Clinical REtina STudy group)|Tokyo Women’s Medical University
Yamanaka, Chihiro J-CREST (Japan Clinical REtina STudy group)|Tokushima University Tokushima University Educator and Researcher Directory
Mitamura, Yoshinori J-CREST (Japan Clinical REtina STudy group)|Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Sugimoto, Masahiko J-CREST (Japan Clinical REtina STudy group)|Mie University
Kondo, Mineo J-CREST (Japan Clinical REtina STudy group)|Mie University
Takamura, Yoshihiro J-CREST (Japan Clinical REtina STudy group)|Fukui University
Ogata, Nahoko J-CREST (Japan Clinical REtina STudy group)|Nara Medical University
Ikeda, Tomohiro J-CREST (Japan Clinical REtina STudy group)|Hyogo College of Medicine
Gomi, Fumi J-CREST (Japan Clinical REtina STudy group)|Hyogo College of Medicine
Content Type
Journal Article
Description
Purpose
To evaluate real-world evidence for intraocular pressure (IOP) elevation after subtenon triamcinolone acetonide injection (STTA) in 1252 Japanese patients (1406 eyes) in the Japan Clinical REtina STudy group (J-CREST).
Methods
This was a multicentre retrospective study of the medical records of 1252 patients (676 men (758 eyes); mean age: 63.8 ± 12.9 years) who received STTA in participating centres between April 2013 and July 2017.
Results
IOP elevation was observed in 206 eyes (14.7%) and IOP increase ≥ 6 mmHg was found in 328 eyes (23.3%). In total, 106 eyes (7.5%) needed medication and two eyes (0.14%) needed surgical procedures. Younger age, higher baseline IOP, and steroid dose were risk factors associated with IOP elevation. Risk factors associated with IOP increase ≥ 6 mmHg were younger age, lower baseline IOP, steroid dose, and higher incidences of diabetic macular oedema (DME) and uveitis. In contrast, with steroid dose fixed at 20 mg, a lower incidence of DME was a risk factor for increased IOP, suggesting that STTA had dose-dependent effects on IOP increase, especially in patients with DME.
Conclusion
Our real-world evidence from a large sample of Japanese patients who received STTA showed that the incidence of IOP elevation after STTA was 14.7%, and was associated with younger age, higher baseline IOP, and steroid dose. Thus, IOP should be monitored, especially in patients with younger age, higher baseline IOP, and higher incidences of DME and uveitis.
Journal Title
PLOS ONE
ISSN
19326203
Publisher
PLOS
Volume
14
Issue
12
Start Page
e0226118
Published Date
2019-12-05
Rights
© 2019 Maeda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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language
eng
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departments
University Hospital
Medical Sciences