| ID | 117855 |
| Author |
Watanabe, Takeshi
Tokyo Medical and Dental University
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Nagamine, Takahiko
Sunlight Brain Research Center
Mikuzuki, Lou
Tokyo Medical and Dental University
Aota, Yuma
Tokyo Medical and Dental University
Suga, Takayuki
Tokyo Medical and Dental University
Tu, Trang T.H
Tokyo Medical and Dental University
Kawasaki, Kaoru
Tokyo Medical and Dental University
Shinohara, Yukiko
Tokyo Medical and Dental University
Takenoshita, Miho
Tokyo Medical and Dental University
Toyofuku, Akira
Tokyo Medical and Dental University
|
| Keywords | amitriptyline
autonomic nervous function
burning mouth syndrome
QTc interval
|
| Content Type |
Journal Article
|
| Description | Backgrounds: Burning mouth syndrome (BMS) is characterized by a burning sensation of the oral mucosa in the absence of underlying dental causes. Only a minority of BMS patients will achieve satisfactory pain relief and little is known about clinical makers for the response. The objective of this study was to consider whether corrected QT interval (QTc) is a useful biomarker for clinical responses.
Methods: We conducted a single-center retrospective observational study and evaluated 51 BMS patients treated with amitriptyline. We calculated QTc changes with amitriptyline and examined the relationship between changes in QTc and visual analogue scale (VAS). Results: Of 51 subjects, 13 (25.5%) were amitriptyline-responders and 38 (74.5%) were non-responders. The changes in QTc interval were significantly correlated with changes in VAS (Spearman's rank correlation coefficient r = 0.389, p = 0.006). Conclusions: Changes in QTc interval may be a non-invasive estimation of clinical responses in BMS patients. |
| Journal Title |
International Medical Journal
|
| ISSN | 24363294
13412051
|
| NCID | AA11031497
|
| Publisher | Japan University of Health Sciences|Japan International Cultural Exchange Foundation
|
| Volume | 26
|
| Issue | 1
|
| Start Page | 13
|
| End Page | 14
|
| Published Date | 2019-02
|
| EDB ID | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
|
| TextVersion |
Publisher
|
| departments |
Medical Sciences
|
