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ID 114632
Title Alternative
Hereditary breast cancer
遺伝性乳癌卵巣癌症候群
Author
Morimoto, Masami The University of Tokushima
Takehara, Emi The University of Tokushima
Sasa, Soichiro The University of Tokushima
Takechi, Hirokazu The University of Tokushima KAKEN Search Researchers
Keywords
HBOC
BRCA
RRSO
CRRM
Content Type
Journal Article
Description
Hereditary breast and ovarian cancer(HBOC)syndrome is an autosomal dominant genetic disease, which represents about 5% of all breast cancers. The pathogenic mutations in the BRCA 1/2genes involved in DNA repair pathway are known to be associated with an increased risk of not only breast cancer and ovarian cancer but also prostate cancer, pancreatic cancer and male breast cancer. The risk reduction management is required for BRCA mutation-positive patients. The surveillance using breast magnetic resonance imaging(MRI)is recommended for early detection of breast cancer in HBOC patients. Furthermore, it has been reported that risk reducing salpingooophorectomy(RRSO)reduces mortality caused by breast cancer and ovarian cancer, and contralateral risk-reducing mastectomy(CRRM)improves the overall survival in postoperative breast cancer patients.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
75
Issue
5-6
Start Page
149
End Page
154
Sort Key
149
Published Date
2019-12-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences
University Hospital