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ID 116895
Title Alternative
Drug-Repositioning Approaches Based on Database
Author
Zamami, Yoshito Tokushima University|Okayama University KAKEN Search Researchers
Keywords
drug repositioning
database
medical information database
life science databases
existing drugs
Content Type
Journal Article
Description
Drug repositioning is a drug discovery strategy in which an existing drug is utilized as a therapeutic agent for a different disease. As information regarding the safety, pharmacokinetics, and formulation of existing drugs is already available, the cost and time required for drug development is reduced. Conventional drug repositioning has been dominated by a method involving the search for candidate drugs that act on the target molecules of an organism in a diseased state through basic research. However, recently, information hosted on medical information and life science databases have been used in translational research to bridge the gap between basic research in drug repositioning and clinical application. Here, we review an example of drug repositioning wherein candidate drugs were found and their mechanisms of action against a novel therapeutic target were identified via a basic research method that combines the findings retrieved from various medical and life science databases.
Journal Title
Frontiers in Pharmacology
ISSN
16639812
Publisher
Frontiers Media S.A.
Volume
12
Start Page
752174
Published Date
2021-11-01
Rights
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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language
eng
TextVersion
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departments
Medical Sciences
University Hospital