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ID 109692
Title Alternative
花粉曝露室のスギ花粉曝露によりスギ花粉症患者に誘発された鼻粘膜ヒスタミンH1受容体mRNA発現亢進に対する抗ヒスタミン薬の影響
Author
Nakagawa, Hideyuki Tokushima University
Sakoda, Takema Rinku General Medical Center
Enomoto, Tadao NPO Japan Health Promotion Supporting Network
Keywords
histamine H1 receptor
antihistamines
allergic rhinitis
cedar pollinosis
environmental exposure unit
Content Type
Thesis or Dissertation
Description
In the present study, we examined the effects of antihistamine on the up-regulation of H1R mRNA in the nasal mucosa of patients with pollinosis induced by controlled exposure to pollen using an environmental exposure unit. Out of 20 patients, we designated 14 responders, whose levels of H1R mRNA in the nasal mucosa were increased after the first pollen exposure and excluded 6 non-responders. Accordingly, the first exposure to pollen without treatment significantly induced both nasal symptoms and the upregulation of H1R mRNA in the nasal mucosa of the responders. Subsequently, prophylactic administration of antihistamine prior to the second pollen exposure significantly inhibited both of the above effects in the responders. Moreover, the nasal expression of H1R mRNA before the second pollen exposure in the responders pretreated with antihistamine was significantly decreased, as compared with that before the first pollen exposure without treatment. These findings suggest that antihistamines suppressed histamine-induced transcriptional activation of H1R gene in the nasal mucosa, in addition to their blocking effect against histamine on H1R, resulting in a decrease of nasal symptoms. These findings further suggest that by their inverse agonistic activity, antihistamines suppress the basal transcription of nasal H1R in the absence of histamine in responders.
Journal Title
Journal of Pharmacological Sciences
ISSN
13478613
NCID
AA11806667
AA12022662
Publisher
Japanese Pharmacological Society|Elsevier
Volume
129
Issue
3
Start Page
183
End Page
187
Published Date
2015-10-30
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201606071012.pdf
論文本文 : LID201606071013.pdf
本論文は,著者Hideyuki Nakagawaの学位論文として提出され,学位審査・授与の対象となっている。
Rights
Copyright: © 2015 Japanese Pharmacological Society. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2953号
Diploma Number
甲医第1286号
Granted Date
2016-03-22
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences
Pharmaceutical Sciences