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ID 117015
Title Alternative
Biotin levels in blood and follicular fluid
Author
Yanagihara, Rie Tokushima University
Yano, Yuya Tokushima University
Hayashi, Noriko Tokushima University
Ohta, Chiaki Tokushima University
Minato, Saki Tokushima University
Aoki, Hidenori Tokushima University
Tamura, Kou Tokushima University
Masaki, Rie Tokushima University
Tachibana, Ayaka Tokushima University
Keywords
biotin
IVF/ICSI
follicular fluid
pregnancy
Content Type
Journal Article
Description
It has been shown that biotin, a water-soluble vitamin (B7), plays roles in reproductive functions, such as oocyte maturation and embryo development, in experimental animals. On the other hand, little is known about the clinical effects of biotin on human reproduction. In this study, serum and follicular fluid biotin levels were measured in patients who underwent in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI), and their associations with reproductive outcomes were evaluated. As a result, biotin was detected in follicular fluid, as well as serum, and the biotin levels of follicular fluid were found to be positively correlated with those of serum. The biotin levels of serum were higher than those of follicular fluid, suggesting that biotin may be taken up into the follicular fluid from the blood. Although serum and follicular fluid biotin levels tended to be higher in pregnant patients than in non-pregnant patients, these data did not show the significant statistical difference. These findings indicate that biotin does not contribute to the maintenance of oocyte quality, and hence, it does not increase fertilization and pregnancy rates.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
69
Issue
1-2
Start Page
65
End Page
69
Sort Key
65
Published Date
2022-02
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
University Hospital
Medical Sciences