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ID 116225
Title Alternative
CEST Power Optimization on Egg White and Its Application to Human Studies
Author
Fushimi, Yasutaka Kyoto University
Sakashita, Naotaka Toshiba Medical Systems Corporation
Okada, Tomohisa Kyoto University
Arakawa, Yoshiki Kyoto University
Miyazaki, Mitsue Toshiba Medical Systems Corporation|Toshiba Medical Research Institute
Keywords
chemical exchange saturation transfer
B0 correction
B1 power
pH dependency
egg white
amide proton transfer
amide proton transfer effect on human brain
Content Type
Journal Article
Description
The chemical exchange saturation transfer (CEST) effect on an egg white (EW) suspension was investigated for optimization of magnetization transfer (MT) power (B1,rms) and pH dependency with the addition of lactic acid. Applying a higher MT pulse, B1,rms, Z-spectrum shows higher asymmetry and the magnetisation transfer ratio (MTR)asym signal increases to around 1–3.5 ppm, indicating a higher CEST effect. Amide proton transfer (APT) at 3.5 ppm shows a signal elevation in MTRasym with the application of higher B1,rms power and high pH. In addition, the hydroxyl proton signal in MTRasym increases as pH is reduced by lactic acid. In Z-spectrum of B1,rms at 1.0 μT and 2.0 μT, the dependence on CEST effect of amide proton and hydroxyl proton could be observed by using an EW suspension phantom. The CEST MT power was optimized on the EW suspension phantom with pH dependency and further confirmed on volunteers. In addition, APT imaging at 3.5 ppm using B1,rms at 1.0 μT performed on two human brains with different pathophysiological conditions indicated appropriate ATP effect.
Journal Title
Magnetic Resonance in Medical Sciences
ISSN
18802206
13473182
NCID
AA11648770
Publisher
Japanese Society for Magnetic Resonance in Medicine
Volume
17
Issue
1
Start Page
86
End Page
94
Published Date
2017-05-31
Rights
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives International License(https://creativecommons.org/licenses/by-nc-nd/4.0/).
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DOI (Published Version)
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language
eng
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departments
Medical Sciences