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ID 114814
Title Alternative
Past infections and low ACPA in RA
Author
Kanamori, Minaho The University of Tokushima
Nagase, Yutaro The University of Tokushima
Kawaminami, Shingo The University of Tokushima
Miyatake, Akiko Yamakami Hospital
Kondo, Keisuke The University of Tokushima
Tabata, Ryo The University of Tokushima KAKEN Search Researchers
Suzuki, Yoshihiro The University of Tokushima
Keywords
rheumatoid arthritis
ACPA
environmental factor
infection
bacteria
Content Type
Journal Article
Description
Background : Rheumatoid arthritis (RA), an autoimmune disease of unknown etiology, is believed to occur as the result of actions of genetic and environmental factors. In this study, we examined the relation of past histories about infectious diseases with the levels anti-citrullinated protein autoantibodies (ACPA) in RA. Methods : Results of a questionnaire about histories of infectious diseases were obtained from 85 patients with RA, and were analyzed. Results : Significantly lower level of ACPA was detected in patients with the history of tonsillitis, otitis media or urinary cystitis than in those without it. There was no difference in the level of ACPA in RA patients between with and without cold / influenza, rubella, chickenpox, herpes labialis or herpes zoster. When RA patients were divided into two groups, high-level and low-level ACPA, multiple logistic regression analysis revealed that the history of otitis media was a significantly independent factor for the low level of ACPA. There was no significant relation between the level of rheumatoid factor and histories of infectious diseases. Conclusion : This study clarified that the past history of otitis media is associated with the low level of ACPA in RA.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA12022913
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
67
Issue
1-2
Start Page
182
End Page
188
Sort Key
182
Published Date
2020-02
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
University Hospital
Medical Sciences