Mano, Takamitsu Tokushima University
Akita, Kazuya Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Fukuda, Naoyuki Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kamada, Kumiko Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kurio, Naito Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ishikawa, Kunio Kyushu University
Since bone apatite is a carbonate apatite containing carbonate in an apatitic structure, carbonate content may be one of the factors governing the osteoconductivity of apatitic bone substitutes. The aim of this study was to evaluate the effects of carbonate content on the osteoconductivity of apatitic bone substitutes using three commercially available bone substitutes for the reconstruction of alveolar bone defects of a beagle mandible with simultaneous dental implant installation. NEOBONE®, Bio-Oss®, and Cytrans® that contain 0.1 mass%, 5.5 mass%, and 12.0 mass% of carbonate, respectively, were used in this study. The amount of newly formed bone in the upper portion of the alveolar bone defect of the beagle’s mandible was 0.7%, 6.6%, and 39.4% at 4 weeks after surgery and 4.7%, 39.5% and 75.2% at 12 weeks after surgery for NEOBONE®, Bio-Oss®, and Cytrans®, respectively. The results indicate that bone-to-implant contact ratio was the largest for Cytrans®. Additionally, the continuity of the alveolar ridge was restored in the case of Cytrans®, whereas the continuity of the alveolar ridge was not sufficient when using NEOBONE® and Bio-Oss®. Both Cytrans® and Bio-Oss® that has a relatively larger carbonate content in their apatitic structure was resorbed with time. We concluded that carbonate content is one of important factors governing the osteoconductivity of apatitic bone substitutes.
Journal of Biomedical Materials Research Part B : Applied Biomaterials
John Wiley & Sons
This is the peer reviewed version of the following article: Mano, T, Akita, K, Fukuda, N, et al. Histological comparison of three apatitic bone substitutes with different carbonate contents in alveolar bone defects in a beagle mandible with simultaneous implant installation. J Biomed Mater Res. 2020; 108: 1450– 1459, which has been published in final form at https://doi.org/10.1002/jbm.b.34492. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
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jbmrb_108_4_1450.pdf 6.18 MB