number of access : ?
number of downloads : ?
ID 113792
Title Alternative
症候性1次性下肢静脈瘤の適切な外科手術は全身性の炎症性物質を軽減する
Systemic Activation of Biomarkers by Varix
Author
Sugasawa, Noriko Tokushima University
Kawatani, Youhei Tokushima University
Keywords
varicose vein
inflammatory biomarkers
IL-6
MCP-1
endovenous laser ablation
Content Type
Thesis or Dissertation
Description
Objective: To evaluate the relationship between systemic inflammatory biomarkers and efficacy of surgical treatment of primary varicose veins of the lower extremities.
Methods: Total 12 patients who underwent endovenous laser ablation or stripping of varicose veins and six healthy subjects were enrolled. Structural and molecular changes of varices were assessed by immunohistochemical staining with anti-monocyte chemotactic protein-1 (MCP-1). MCP-1 and interleukin-6 (IL-6) levels in systemic antecubital blood were measured before and at 12 weeks after treatment.
Results: Immunohistochemical staining revealed prominent manifestation of MCP-1-positive endothelial cells in the walls of varices. Preoperative serum MCP-1 and IL-6 levels in the patients were significantly higher than those in the control (166±12 pg/mL vs 99±10 pg/mL, p=0.003; 5.1±0.95 pg/mL vs 0.0±0.0 pg/mL, p=0.001, respectively). The values were significantly correlated with the severity of chronic venous insufficiency (CVI). Postoperative serum MCP-1 level significantly decreased compared with the preoperative level (152±10 pg/mL vs 166±12 pg/mL, p=0.048). The values after endovenous laser ablation did not significantly decrease compared with those after stripping.
Conclusion: Varicose veins with CVI increase inflammatory biomarker levels in the local tissue and systemic blood. Appropriate treatment of symptomatic varicose veins decreases inflammatory biomarker levels.
Journal Title
Annals of Vascular Diseases
ISSN
1881641X
18816428
NCID
AA12366253
Publisher
The Editorial Committee of Annals of Vascular Diseases
Volume
12
Issue
3
Start Page
367
End Page
371
Published Date
2019-08-05
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Hiroki Araseの学位論文として提出され,学位審査・授与の対象となっている。
Rights
©2019 The Editorial Committee of Annals of Vascular Diseases.
This article is distributed under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided the credit of the original work, a link to the license, and indication of any change are properly given, and the original work is not used for commercial purposes. Remixed or transformed contributions must be distributed under the same license as the original.
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3335号
Diploma Number
甲医第1429号
Granted Date
2019-09-26
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences