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ID 115675
Title Alternative
尿中アディポネクチン排泄は糖尿病患者における腎機能低下の早期予測指標である。
Urinary adiponectin in DKD
Author
Ishizu, Masashi Tokushima University
Ohishi, Mami Tokushima University
Akehi, Yuko Tokushima University
Aiba, Motohiro Tokushima Bunri University
Kawano, Tomoharu Tokushima Bunri University
Hashida, Seiichi Ehime University
Keywords
diabetes kidney disease
urinary adiponectin
estimated glomerular filtration rate
Content Type
Thesis or Dissertation
Description
Aims: Since diabetes-associated kidney complication changes from diabetic nephropathy to diabetic kidney disease (DKD), more suitable biomarkers than urinary albumin are required. It has been hypothesized that urinary adiponectin (u-ADPN) is associated with the progression of DKD. We therefore evaluated the effectiveness of u-ADPN in predicting the decline of the renal function in patients with diabetes prior to end-stage renal disease.
Methods: An ultrasensitive immune complex transfer enzyme immunoassay (ICT-EIA) was used to measure total and high molecular weight (HMW) adiponectin separately. We evaluated the relationships between the creatinine-adjusted urinary total-ADPN and HMW-ADPN, albumin (UACR) and liver-type fatty acid binding protein (L-FABP) at baseline and the 2-year change of the estimated glomerular filtration rate (ΔeGFR).
Results: This 2-year prospective observational study included 201 patients with diabetes. These patients were divided into three groups according to their ΔeGFR: ≤-10 ml/min/1.73m2, >-10 and ≤0 ml/min/1.73m2, and >0 ml/min/1.73m2. Jonckheere-Terpstra test showed that lower ΔeGFR was associated with higher u-HMW-ADPN (p = 0.045). In logistic regression analysis, u-HMW-ADPN was associated with ΔeGFR after adjusted age, sex, and basal eGFR.
Conclusion: Urinary HMW-ADPN could predict a declining renal function in patients with diabetes.
Journal Title
Journal of Diabetes and its Complications
ISSN
10568727
NCID
AA10843748
AA11531864
Publisher
Elsevier
Volume
35
Issue
4
Start Page
107848
Published Date
2021-01-07
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Masashi Ishizuの学位論文として提出され,学位審査・授与の対象となっている。
Rights
© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3503号
Diploma Number
甲医第1489号
Granted Date
2021-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Institute of Advanced Medical Sciences
Medical Sciences