Dynapenia and sarcopenia diabetes
Mori, Hiroyasu Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kuroda, Akio Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yasuda, Tetsuyuki Osaka Police Hospital
Umayahara, Yutaka Osaka General Medical Center
Shimizu, Sayoko Osaka General Medical Center
Ryomoto, Kayoko Osaka Rosai Hospital
Yoshiuchi, Kazutomi Osaka Kaisei Hospital
Yamamoto, Tsunehiko Kansai Rosai Hospital
Matsuoka, Taka-aki Osaka University
Shimomura, Iichiro Osaka University
Type 1 and type 2 diabetes
Aims/Introduction: The present study aimed to clarify the prevalence and clinical characteristics of sarcopenia and dynapenia, which are muscle weakness with and without low muscle mass, respectively, in Japanese patients with type 1 diabetes mellitus and type 2 diabetes mellitus.
Materials and Methods: This cross-sectional study enrolled 1,328 participants with type 1 diabetes (n = 177), type 2 diabetes (n = 645) and without diabetes (n = 506). Sarcopenia was defined as a low grip strength and slow gait speed with low skeletal muscle mass index, whereas dynapenia was defined as low strengths of grip and knee extension with a normal skeletal muscle mass index. Participants without sarcopenia and dynapenia were defined as robust.
Results: Among participants aged ≥65 years, sarcopenia and dynapenia were observed in 12.2% and 0.5% of individuals without diabetes, 42.9% and 11.4% of type 1 diabetes patients, and 20.9% and 13.9% of type 2 diabetes patients. In both type 1 diabetes and type 2 diabetes patients, sarcopenic patients were significantly older and thinner, and showed a significantly higher rate of diabetic neuropathy than robust patients. In patients with type 1 diabetes and type 2 diabetes, dynapenic patients were older, and showed a higher rate of diabetic neuropathy and lower estimated glomerular filtration rate than robust patients. Patients complicated with sarcopenia and dynapenia showed a significantly lower physical quality of life and higher rate of incidental falls than robust patients.
Conclusions: Sarcopenia and dynapenia were more frequent in patients with type 1 diabetes and type 2 diabetes than in individuals without diabetes, which might contribute to their impaired quality of life and incidental falls.
Journal of Diabetes Investigation
Asian Association for the Study of Diabetes|John Wiley & Sons
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Institute of Advanced Medical Sciences