number of access : ?
number of downloads : ?
ID 116069
Title Alternative
A clinical study on malignant lymphomas arising in the oral region
Author
Mano, Takamitsu Tokushima University
Yokota, Miho Tokushima University
Keywords
悪性リンパ腫
臨床試験
口腔領域
リンパ球/単球数比
malignant lymphoma
clinical study
oral region
lymphocyte-monocyte ratio
Content Type
Journal Article
Description
2008年から2018年までの11年間に当科で口腔領域に発症した悪性リンパ腫の18例について臨床的特徴を調べた。患者は,平均年齢が70.2歳の男性10例,女性8例であった。原発部位の10例(55.6%)は上顎歯肉で,初期症状は15例(83.3%)で腫瘤と腫脹であった。7例(38.9%)が初診時に臨床的に悪性リンパ腫と診断されたが,その他の11例は正しく診断することが困難であった。腫瘤形成や潰瘍のような様々な臨床症状が診断を困難にしており,1回の生検では確定診断が得られなかった。そこで,血液検査値が診断の指標であるかどうかを検討した。われわれの結果は,17例中8例のLDH(47.1%)と16例中11例のsIL-2R(68.8%)が高い値を示していた。さらに,われわれはリンパ球/単球数比(LMR)が診断に役立つかどうかを調べた。LMRの値は,17例中13例(76.5%)が有意に低く,非ML患者と比較しても有意差を認めた。以上のことより,LMRの血液検査も診断の補助的なマーカーであると考えられた。
Description Alternative
We examined the clinical characteristics of 18 cases of malignant lymphomas arising in the oral region which were diagnosed at our department during the 11 years from 2008 to 2018. The patients consisted of 10 males and 8 females whose mean age was 70.2 years. The primary site was the upper gingiva in 10 cases (55.6%), and the initial symptoms were tumor mass and swelling in 15 cases (83.3%). Only 7 cases (38.9%) were clinically diagnosed as malignant lymphoma at first visit, but the other 11 cases were difficult to diagnose correctly. The various clinical symptoms such as mass formation and ulcer made differential diagnosis difficult, and a definitive diagnosis could not be obtained by only a single biopsy. Therefore, we examined whether blood test results might be used as an indicator of the diagnosis or not. Our results showed that LDH in 8 of 17 cases (47.1%) and sIL-2R in 11 of 16 cases (68.8%) were high values. Furthermore, we examined whether lymphocyte-monocyte ratio (LMR) helped the diagnosis or not. Thirteen of 17 cases (76.5%) showed a low value of LMR. There was a significant difference in LMR compared to non-malignant lymphoma patients. LMR in the blood tests was also considered to be a useful marker for the diagnosis.
Journal Title
Journal of Japanese Society of Oral Oncology
ISSN
09155988
18844995
NCID
AN10170059
Publisher
日本口腔腫瘍学会
Volume
33
Issue
2
Start Page
35
End Page
40
Published Date
2021
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
jpn
TextVersion
Publisher
departments
University Hospital
Oral Sciences