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ID 115594
Title Alternative
Gastroduodenal Mucosal Injury and Antiplatelet Drug Users
Author
Sogabe, Masahiro Tokushima University|Kagawa Prefectural Cancer Detection Center Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nakasono, Masahiko Tsurugi Municipal Handa Hospital
Takaoka, Yoshihumi Tokushima University
Content Type
Journal Article
Description
Antiplatelet drugs are widely used for the prevention of cardiovascular disease and cerebral vascular disorders. Although there have been several studies on gastroduodenal mucosal injury with gastrointestinal (GI) symptoms such as GI bleeding, in antiplatelet drug users (including low-dose aspirin (LDA)), there have been few reports on the association between antiplatelet drug use and gastroduodenal mucosal injury in asymptomatic antiplatelet drug users. This study was a cross-sectional study elucidating the association between antiplatelet drug use and gastroduodenal mucosal injury in asymptomatic antiplatelet drug users.
Subjects were 186 asymptomatic Japanese antiplatelet drug users who underwent a regular health checkup. Subjects were divided into those with and without gastroduodenal mucosal injury endoscopically, and the association between gastroduodenal mucosal injury and other data in asymptomatic antiplatelet drug users was investigated.
The prevalence of males and drinkers were significantly higher in subjects with gastroduodenal mucosal injury than in those without. In addition, the prevalence of proton pump inhibitor (PPI) users was significantly lower in subjects with gastroduodenal mucosal injury than in subjects without gastroduodenal mucosal injury. Logistic regression analysis showed PPI (odds ratios: 0.116; 95% confidence intervals: 0.021–0.638; P < 0.05) was a significant predictor of a decreased prevalence of gastroduodenal mucosal injury and closed-type (C-type) atrophy (3.172; 1.322–7.609; P < 0.01) was a significant predictor of an increased prevalence of severe gastroduodenal mucosal injury in asymptomatic antiplatelet drug users.
Gender and lifestyle, such as drinking, may have an impact on risk of gastroduodenal mucosal injury in asymptomatic subjects taking antiplatelet drugs. Although PPI is a significant predictor of a decreased prevalence of gastroduodenal mucosal injury, including in asymptomatic antiplatelet drug users, status of gastric atrophy should also be considered against severe gastroduodenal mucosal injury.
Journal Title
Medicine
ISSN
00257974
15365964
NCID
AA00728867
Publisher
Wolters Kluwer Health
Volume
94
Issue
26
Start Page
e1047
Published Date
2015-07
Rights
This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0(https://creativecommons.org/licenses/by-nc-nd/4.0/), where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially.
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language
eng
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departments
Medical Sciences
University Hospital