number of access : ?
number of downloads : ?
ID 105887
Title Alternative
日本人における魚介類摂取頻度、血清肝機能酵素とPFOS、PFOAの血液中濃度
Seafood, Serum Liver Enzymes, PFOS and PFOA in Blood
Author
Yamaguchi, Miwa Department of Preventive Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Uemura, Hirokazu The University of Tokushima KAKEN Search Researchers
Takami, Hidenobu The University of Tokushima
Sawachika, Fusakazu The University of Tokushima
Juta, Tomoya The University of Tokushima
Toda, Eisaku Ministry of the Environment of Japan
Mori, Kei Ministry of the Environment of Japan
Hasegawa, Manabu Ministry of the Environment of Japan
Tanto, Masaharu Ministry of the Environment of Japan
Shima, Masayuki Ministry of the Environment of Japan
Sumiyoshi, Yoshio Ministry of the Environment of Japan
Kodama, Kazunori Ministry of the Environment of Japan
Suzuki, Takaichiro Ministry of the Environment of Japan
Nagai, Masaki Ministry of the Environment of Japan
Satoh, Hiroshi Ministry of the Environment of Japan
Keywords
Blood
Fish intake
Perfluorooctanesulfonate (PFOS)
Perfluorooctanoate (PFOA)
Serum liver enzymes
Content Type
Thesis or Dissertation
Description
Objective: Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) have been shown to accumulate in the human body. The purpose of the present study was to examine the factors associated with the blood levels of PFOS and PFOA. Methods: A cross-sectional study was performed on 307 men and 301 women (aged 16−76 years) living in 15 prefectures in Japan. Blood levels of PFOS and PFOA were measured by liquid chromatography-mass spectrometry. Hepatic enzymes (γ-GTP, GOT, and GPT) and ω-3 polyunsaturated fatty acids (DHA and EPA) levels in serum were also measured. Associations between the levels of PFOS and PFOA in blood and the intake frequency of 41 kinds of dishes, foods and beverages and the serum levels of liver enzymes and ω-3 polyunsaturated fatty acids were examined using rank correlations. Results: Frequency of intake of boiled fish in broth, sliced raw fish and coastal fish showed significant positive correlations with PFOS concentrations in blood after adjustments for potential confounders. Serum levels of GOT, GPT, DHA and EPA showed significant positive correlations with PFOS and PFOA in blood. There was also a significant regional difference in the blood levels of PFOS and PFOA, with medians being highest in the Tokai/Hokuriku/Kinki region. Conclusions: These findings suggest that the concentrations of PFOS in blood were mainly associated with fish consumption and that the levels of PFOS and PFOA were associated with the serum levels of liver enzymes in Japanese populations. Further investigations are required to clarify the reason for the regional differences in blood levels of PFOS and PFOA in Japan.
Journal Title
Journal of Occupational Health
ISSN
13489585
13419145
NCID
AA11090645
AA11510660
Publisher
Japan Society for Occupational Health|Wiley
Volume
55
Issue
3
Start Page
184
End Page
194
Published Date
2013-04-09
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201308190002.pdf
論文本文 : LID201405230001.pdf
本論文は, 著者Miwa Yamaguchiの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
LID201405230001.pdf 256 KB ( 限定公開 )
language
eng
TextVersion
ETD
MEXT report number
甲第2617号
Diploma Number
甲医第1162号
Granted Date
2013-05-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences