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ID 117853
Author
Sogabe, Masahiro Tokushima University|Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Okahisa, Toshiya Tokushima University|Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kurihara, Takeshi Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers
Kagawa, Miwako Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers
Ueda, Hiroyuki Tokushima University|Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers
Kawaguchi, Tomoyuki Tokushima University|Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers Tokushima University Educator and Researcher Directory
Fukuya, Akira Tokushima University|Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers KAKEN Search Researchers
Kagemoto, Kaizo Tokushima University
Nakasono, Masahiko Tsurugi Municipal Handa Hospital
Content Type
Journal Article
Description
The clinical difference between nonalcoholic fatty liver disease (NAFLD) and metabolic-associated fatty liver disease (MAFLD) between the two sexes is unclear. This study aimed to determine the influences of alcohol consumption and qualitative abdominal fat between male and female patients with NAFLD and MAFLD. This cross-sectional study examined 11,766 participants who underwent health check-ups comparing lifestyle habits, biochemical features, and noninvasive liver fibrosis scores, between non-MAFLD and MAFLD groups. Furthermore, differences in alcohol consumption and qualitative abdominal fat were examined between male and female patients with NAFLD and MAFLD. The prevalence of metabolic dysregulation, ratio of visceral fat area to subcutaneous fat area, and noninvasive liver fibrosis scores were significantly higher in male patients with MAFLD than in those with NAFLD (p < 0.05), but these were not significantly different in female patients. Among male patients with an alcohol consumption of > 70 g/week, several noninvasive liver fibrosis scores were significantly higher in the MAFLD group than in the NAFLD group (all p < 0.05). The influences of alcohol consumption and qualitative abdominal fat on NAFLD and MAFLD were different between sexes. The development of liver fibrosis should be considered in male patients with MAFLD who exceed mild drinking.
Journal Title
Scientific Reports
ISSN
20452322
Publisher
Springer Nature
Volume
12
Start Page
16048
Published Date
2022-09-26
Rights
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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language
eng
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departments
Medical Sciences
University Hospital