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ID 112753
Title Alternative
正常マウスにおける軸索HCN電流へ麻酔薬が及ぼす影響
Author
Banzrai, Chimeglkham Tokushima University
Endo, Sachiko Tokushima University
Takayasu, Hirokazu Tokushima University
Mori, Atsuko Tokushima University
Shimatani, Yoshimitsu Tokushima University
Keywords
Axonal excitability
Anesthetics
HCN channel
Content Type
Thesis or Dissertation
Description
Objective: The objective was to study the in vivo effects of anesthetic agents on peripheral nerve excitability.
Methods: Normal male mice were anesthetized by either isoflurane inhalation or a combination of medetomidine, midazolam, and butorphanol intraperitoneal injection (‘‘triple agents’’). Immediately after induction, the tail sensory nerve action potential was recorded and its excitability was monitored.
Results: Under both anesthetic protocols, there was an interval excitability change by long hyperpolarizing currents. There was greater threshold reduction approximately 30 min post induction, in comparison to immediately post induction. Other excitability parameters were stable over time. Modeling suggested interval suppression of internodal H conductance or leak current.
Conclusions: Anesthetic agents affected responses to long hyperpolarizing currents. Significance: Axonal excitability during intraoperative monitoring may be affected by anesthetic agents. Interpretation of interval excitability changes under anesthesia requires caution, especially with long hyperpolarizing currents.
Journal Title
Clinical Neurophysiology
ISSN
13882457
NCID
AA11523403
AA11309888
Publisher
Elsevier
Volume
126
Issue
10
Start Page
2033
End Page
2039
Published Date
2015-01-19
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Yusuke Osakiの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3207号
Diploma Number
甲医第1381号
Granted Date
2018-09-13
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences