A gene expression test for depression
Watanabe, Shin-ya Tokushima University KAKEN Search Researchers
Numata, Shusuke Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Iga, Jun-ichi Ehime University KAKEN Search Researchers
Kinoshita, Makoto Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Umehara, Hidehiro Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ishii, Kazuo Tokyo University of Agriculture and Technology
Purpose: Recently, we could distinguished patients with major depressive disorder (MDD) from nonpsychiatric controls with high accuracy using a panel of five gene expression markers (ARHGAP24, HDAC5, PDGFC, PRNP, and SLC6A4) in leukocyte. In the present study, we examined whether this biological test is able to discriminate patients with MDD from those without MDD, including those with schizophrenia and bipolar disorder.
Patients and methods: We measured messenger ribonucleic acid expression levels of the aforementioned five genes in peripheral leukocytes in 17 patients with schizophrenia and 36 patients with bipolar disorder using quantitative real-time polymerase chain reaction (PCR), and we combined these expression data with our previous expression data of 25 patients with MDD and 25 controls. Subsequently, a linear discriminant function was developed for use in discriminating between patients with MDD and without MDD.
Results: This expression panel was able to segregate patients with MDD from those without MDD with a sensitivity and specificity of 64% and 67.9%, respectively.
Conclusion: Further research to identify MDD-specific markers is needed to improve the performance of this biological test.
Neuropsychiatric Disease and Treatment
Dove Medical Press
© 2017 Watanabe et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
|DOI (Published Version)|
|URL ( Publisher's Version )|
ndt_13_535.pdf 487 KB