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ID 118732
Title Alternative
sdLDL-C and Cardiovascular Events
Author
Yamaji, Takayuki Hiroshima University
Harada, Takahiro Hiroshima University
Kajikawa, Masato Hiroshima University
Maruhashi, Tatsuya Hiroshima University
Kishimoto, Shinji Hiroshima University
Mohamad Yusoff, Farina Hiroshima University
Chayama, Kazuaki Hiroshima University
Goto, Chikara Hiroshima International University
Nakashima, Ayumu Hiroshima University
Tomiyama, Hirofumi Tokyo Medical University
Takase, Bonpei National Defense Medical College Research Institute
Kohro, Takahide Jichi Medical University
Suzuki, Toru University of Leicester
Ishizu, Tomoko University of Tsukuba
Ueda, Shinichiro University of the Ryukyu
Yamazaki, Tsutomu The University of Tokyo
Furumoto, Tomoo Hokkaido University
Kario, Kazuomi Jichi Medical University
Inoue, Teruo Dokkyo Medical University
Watanabe, Kentaro Yamagata University
Takemoto, Yasuhiko Osaka Metropolitan University
Hano, Takuzo Wakayama Medical University
Ishibashi, Yutaka Shimane University
Node, Koichi Saga University
Maemura, Koji Nagasaki University
Ohya, Yusuke University of the Ryukyus
Furukawa, Taiji Teikyo University
Ito, Hiroshi Okayama University
Yamashina, Akira Tokyo Medical University
Koba, Shinji Showa University
Higashi, Yukihito Hiroshima University
Keywords
Small dense low-density lipoprotein cholesterol
Triglycerides
Type 2 diabetes mellitus
Statin
Cardiovascular events
Content Type
Journal Article
Description
Aim: There is little information on the relationships of serum small dense low-density lipoprotein cholesterol (sdLDL-C) levels and serum triglyceride (TG) levels with cardiovascular events in patients with coronary artery disease (CAD) and type 2 diabetes mellitus (DM) who are receiving statins. The aim of this study was to evaluate the relationships of serum TG levels and sdLDL-C levels as residual risks for cardiovascular events in patients with CAD and type 2 DM who were being treated with statins.
Methods: The subjects were divided into four groups based on TG levels and sdLDL-C levels: sdLDL-C of <40.0 mg/dL and TG of <150 mg/dL, sdLDL-C of ≥ 40.0 mg/dL and TG of <150 mg/dL, sdLDL-C of <40.0 mg/dL and TG of ≥ 150 mg/dL, and sdLDL-C of ≥ 40.0 mg/dL and TG of ≥ 150 mg/dL. During a median follow-up period of 1419 days, cardiovascular events occurred in 34 patients.
Results: The incidences of cardiovascular events were significantly higher in patients with sdLDL-C of ≥ 40.0 mg/dL and TG of <150 mg/dL and in patients with sdLDL-C of ≥ 40.0 mg/dL and TG of ≥ 150 mg/dL, but not in patients with sdLDL-C of <40.0 mg/dL and TG of ≥ 150 mg/dL, than in patients with sdLDL-C of <40.0 mg/dL and TG of <150 mg/dL.
Conclusions: Under the condition of treatment with statins, patients with CAD and type 2 DM who had sdLDL-C levels of ≥ 40.0 mg/dL had a high risk for cardiovascular events even though serum TG levels were controlled at <150 mg/dL.
Journal Title
Journal of Atherosclerosis and Thrombosis
ISSN
18803873
13403478
Publisher
Japan Atherosclerosis Society
Volume
31
Issue
4
Start Page
478
End Page
500
Published Date
2024-04-01
Rights
This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc-sa/4.0/).
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DOI (Published Version)
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language
eng
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departments
Medical Sciences