ID | 110960 |
Title Alternative | 大腸癌における抗EGFR抗体薬治療後のEGFR Downregulationは抗腫瘍効果を予測する
EGFR Down-regulation Predicts anti-EGFR Response
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Author |
Okamoto, Koichi
Tokushima University
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Fujimoto, Shota
Tokushima University
Sogabe, Masahiro
Tokushima University
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Miyamoto, Hiroshi
Tokushima University
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Muguruma, Naoki
Tokushima University
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Tsuji, Yasushi
Tonan Hospital
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Keywords | Colorectal cancer
EGFR
cetuximab
internalization
degradation
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Content Type |
Thesis or Dissertation
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Description | ABC, antibody-binding capacity; ADCC, antibody-dependent cellular cytotoxicity; ATCC, American Type Culture Collection; BSA, bovine serum albumin; CR, complete response; CRC, colorectal cancer; CT, computed tomography; ECACC, European Collection of Authenticated Cell Cultures; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; ETS, early tumor shrinkage; FBS, fetal bovine serum; FISH, fluorescent in situ hybridization; HRP, horseradish peroxidase; HSRRB, Health Science Research Resources Bank; IHC, immunohistochemistry; MesNa, Mercaptoethanesulfonic acid sodium; mCRC, metastatic colorectal cancer; mAb, monoclonal antibody; mAbs, monoclonal antibodies; PARP, poly (ADP-ribose) polymerase; PBS, phosphate buffered saline; PD, progressive disease; p-ERK, phosphorylated ERK; PNA-LNA, peptide nucleic acid-locked nucleic acid; PR, partial response; PVDF, polyvinylidene difluoride; RECIST, Response Evaluation Criteria in Solid Tumors; RIKEN BRC, RIKEN BioResource Center; SD, stable disease; SDS, sodium dodecyl sulfate; SDS-PAGE, SDS-polyamide gel electrophoresis; TBS-T, Tris-buffered saline with 0.1% Tween; TGF-α, transforming growth factor-α.
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Journal Title |
Molecular Cancer Research
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ISSN | 15417786
15573125
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NCID | AA11795083
AA12004955
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Publisher | American Association for Cancer Research
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Volume | 15
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Issue | 10
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Start Page | 1445
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End Page | 1454
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Published Date | 2017-07-11
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Remark | 内容要旨・審査要旨・論文本文の公開
本論文は, 著者Yasuyuki Okadaの学位論文として提出され, 学位審査・授与の対象となっている。 |
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第3116号
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Diploma Number | 甲医第1351号
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Granted Date | 2017-10-26
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Degree Name |
Doctor of Medical Science
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Grantor |
Tokushima University
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departments |
Medical Sciences
University Hospital
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