ID | 116676 |
Author |
Wada, Yuma
The University of Tokushima
Tokushima University Educator and Researcher Directory
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Morine, Yuji
The University of Tokushima
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Ikemoto, Tetsuya
The University of Tokushima
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Saito, Yu
The University of Tokushima
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Takasu, Chie
The University of Tokushima
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Yamada, Shinichiro
The University of Tokushima
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Shimada, Mitsuo
The University of Tokushima
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Keywords | Colorectal liver metastasis
HIF-1α
Prognostic factor
Molecular biology
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Content Type |
Journal Article
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Description | Background: The role of hypoxia-inducible factor-1α (HIF-1α) in primary colorectal cancer (CRC) and colorectal liver metastasis (CRLM) has remained unclear. The aim of this study was to investigate HIF-1α expression and its association with prognosis in patients with CRLM with a focus on hepatic stellate cells (HSCs).
Methods: Colon cancer cells were cultured in HSC-conditioned medium (CM), and HIF-1α expression and cell migration were analyzed. Seventy-five patients with CRLM who underwent an initial curative hepatectomy were enrolled. We examined HIF-1α expressions and patient prognosis between primary CRCs and the matched liver metastatic specimens. Results: Activated HSCs induced HIF-1α mRNA and protein expression in colon cancer cells (p < 0.01) and promoted cell migration (p < 0.01). The positive rates of HIF-1α expression in primary CRCs and liver metastases were 68.0 and 72.0%, respectively. There were no differences in overall (OS) and disease-free survival (DFS) of HIF-1α expression in primary CRC. However, HIF-1α expression in liver metastasis correlated to poor prognosis in both OS and DFS. Furthermore, patients with HIF-1α positive expression in liver metastasis had poor prognosis. Conclusion: HIF-1α expression in liver metastasis determines poor prognosis of CRLM patients. HSCs might play a key role in aggressive phenotypes of tumor cells. |
Journal Title |
World Journal of Surgical Oncology
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ISSN | 14777819
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Publisher | BioMed Central|Springer Nature
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Volume | 18
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Start Page | 241
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Published Date | 2020-09-07
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Rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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DOI (Published Version) | |
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language |
eng
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Publisher
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departments |
University Hospital
Medical Sciences
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