Total for the last 12 months
number of access : ?
number of downloads : ?
ID 119337
Title Alternative
乳癌患者における化学療法の有害事象 : CTCAE、PRO-CTCAEおよびEORTC QLQ-C30を用いた検討
Adverse events of chemotherapy in breast cancer
Author
Arahori, Hiromi Tokushima University
Keywords
Breast cancer
CTCAE
PRO-CTCAE
EORTC QLQ-C30
Chemotherapy
Content Type
Thesis or Dissertation
Description
Background : The Common Terminology Criteria for Adverse Events (CTCAE) is used as a tool to evaluate the adverse events (AE) of chemotherapy in cancer patients. Since CTCAE by medical providers underestimates AE more than patient-reported outcomes (PRO), the National Cancer Institute developed PRO-CTCAE. The present study investigated differences between symptoms detected using CTCAE by medical providers and PRO-CTCAE by breast cancer patients. Methods : Patients received chemotherapy comprising epirubicin and cyclophosphamide pre- or postoperatively. AE were evaluated using 4 questionnaires : PRO-CTCAE, CTCAE, the European Organization for Research and Treatment of Cancer-Quality of Life Questionnaire (EORTC-QLQ-30), and Hospital Anxiety and Depression Scale (HADS) after 1, 2, and 3 courses of chemotherapy. Results : Forty-two patients were registered. Regarding the recognition of psychological symptoms, such as fatigue, anxiety, and discouragement, and subjective symptoms, including heart palpitations and shortness of breath, PRO using PRO-CTCAE was significantly higher than medical provider-recognized outcomes using CTCAE. Concerning the recognition of regimen-specific symptoms, such as vomiting, nausea, and decreased appetite, medical provider-recognized outcomes were the same or higher than PRO. In QLQ-C30, the physical and role functions, fatigue and dyspnea significantly worsened after 2 and 3 courses of chemotherapy.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
71
Issue
1-2
Start Page
82
End Page
91
Sort Key
82
Published Date
2024-02
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Hiromi Arahoriの学位論文として提出され,学位審査・授与の対象となっている。
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3803号
Diploma Number
甲保第66号
Granted Date
2024-03-22
Degree Name
Doctor of Health Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital