| ID | 110431 |
| Title Transcription | ハイガン カンジャ ケッセイチュウ ニオケル ガン ヨクセイ イデンシ サンブツ pRB ニタイスル コウタイ ノ ケンシュツ
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| Title Alternative | Detection of anti-pRB antibodies in sera of lung cancer patients
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| Author |
Yamamoto, Yuiko
Department of Clinical Pharmacology, Faculty of Pharmaceutical Science, The University of Tokushima|Third Department of Internal Medicine, The University of Tokushima School of Medicine
Shimizu, Eiji
Third Department of Internal Medicine, The University of Tottori School of Medicine
Yokota, Masayuki
Department of Clinical Pharmacology, Faculty of Pharmaceutical Science, The University of Tokushima
Sone, Saburo
Third Department of Internal Medicine, The University of Tokushima School of Medicine
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| Keywords | tumor suppressor gene
pRB
serum
autoantibody
lung cancer
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| Content Type |
Journal Article
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| Description | Recently, serum antibodies against the oncogene and tumor suppressor gene products have been studied in patients with various types of cancer. Antibody against p53 tumor suppressor gene product among these antibodies was suggested to be useful for early diagnosis and evaluation of prognosis of patients with some types of cancer. In this article,we review clinical significance of antibodies against product of retinoblastoma gene (pRB),one of representative tumor suppressor genes. We also describe methods of detection of antibodies in sera from patients with lung cancer by immunoblotting assays using glutathione-S-transferase (GST)-RB fusion proteins.
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| Journal Title |
四国医学雑誌
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| ISSN | 00373699
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| NCID | AN00102041
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| Publisher | 徳島医学会
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| Volume | 56
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| Issue | 1
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| Start Page | 1
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| End Page | 12
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| Sort Key | 1
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| Published Date | 2000-02-25
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| FullText File | |
| language |
jpn
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| TextVersion |
Publisher
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| departments |
Medical Sciences
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