number of access : ?
number of downloads : ?
ID 109502
Title Alternative
新規アポトーシス関連タンパク質ヌクリングはNF-κBとSTAT3の調節を介して乳腺退縮を制御する
Nucling Regulates Mammary Gland Involution
Author
Van Dang, Huy Tokushima University
Sakai, Takashi Tokushima University|Tokushima Bunri University KAKEN Search Researchers
Anh Pham, Tuan Tokushima University|Vietnam National University
Hong Tran, Diem Tokushima University|Vietnam National University
Keywords
apoptosis
macrophage
NF-κB
STAT3
nucling
mammary gland involution
Content Type
Thesis or Dissertation
Description
Postpartum mammary gland involution is the physiological process by which the lactating gland returns to its pre-pregnant state. In rodent models, the microenvironment of mammary gland involution is sufficient to induce enhanced tumor cell growth, local invasion, and metastasis. Therefore, a deeper understanding of the physiological regulation of involution may provide in-depth information on breast cancer therapy. We herein identified Nucling as an important regulator of involution of the mammary gland. A knock-out mouse model was generated and revealed that postpartum involution were impaired in mice lacking Nucling. Involution is normally associated with an increase in the activation of NF-κB and STAT3, which is required for the organized regulation of involution, and was observed in WT glands, but not in the absence of Nucling. Furthermore, the loss of Nucling led to the suppression of Calpain- 1, IL-6, and C/EBPδ factors, which are known to be essential for normal involution. The number of M2 macrophages, which are crucial for epithelial cell death and adipocyte repopulation after weaning, was also reduced in Nucling-KO glands. Taken together, the results of the present study demonstrated that Nucling played an important role in mammary gland involution by regulating NF-κB and STAT3 signaling pathways.
Journal Title
Journal of Biological Chemistry
ISSN
1083351X
NCID
AA1202441X
Publisher
American Society for Biochemistry and Molecular Biology
Volume
290
Issue
40
Start Page
24626
End Page
24635
Published Date
2015-08-11
Remark
内容要旨・審査要旨・論文全文の公開:
内容要旨・審査要旨 : LID201510261009.pdf
論文全文 : k2883_fulltext.pdf
著者の申請により要約(2015-10-26公開)に替えて論文全文を公開(2018-12-05)
本論文は, 著者Huy Van Dangの学位論文として提出され, 学位審査・授与の対象となっている。
Rights
© the American Society for Biochemistry and Molecular Biology.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2883号
Diploma Number
甲医第1260号
Granted Date
2015-09-24
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Institute of Advanced Medical Sciences