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ID 116827
Author
Wada, Riona Tokushima University
Yanase, Masatoshi Tokushima University
Tomiyama, Erina Tokushima University
Higuchi, Keiro Ogawa & Co., Ltd.
Keywords
Amplitude modulated flow analysis
flow rate modulation
triangular-wave control
fast Fourier transform
saturated signal
Content Type
Journal Article
Description
We have applied our amplitude-modulated flow analysis concept to extend the dynamic range to saturated analytical signals. Sample solution, the flow rate FS of which is periodically varied with a triangular control signal Vc, is merged with a reagent solution delivered at a constant flow rate FR. While the total flow rate FT is kept constant, a diluent with FT – (FS + FR) flow rate is aspirated from the third channel. The analytical signal Vd obtained downstream is processed by fast Fourier transform to obtain the amplitudes of the wave components in Vd. When the sample concentration CS is low, Vd shows a triangular profile like Vc; the sum of the amplitudes ΣA is proportional to CS. When CS is high, Vd shows a trapezoidal profile because of the Vd saturation. A linear calibration curve can also be obtained for such saturated signals by plotting CSΣA against CS. The proof of the concept is validated by applying it to spectrophotometric determinations of a dye (Methylene Blue) and colored complexes of Fe2+−phenanthroline and Fe3+−Tiron.
Journal Title
Analytical Sciences
ISSN
13482246
09106340
NCID
AA10500785
Publisher
The Japan Society for Analytical Chemistry|Springer Nature
Volume
38
Issue
5
Start Page
795
End Page
802
Published Date
2022-03-17
Remark
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use (https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s44211-022-00097-4
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DOI (Published Version)
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language
eng
TextVersion
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departments
Pharmaceutical Sciences
Science and Technology