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ID 113741
Title Alternative
The mechanism of skeletal muscle atrophy : finding from space experiment
Author
Keywords
Unloading stress
Muscle atrophy
Mitochondria
Reactive oxygen species
Content Type
Journal Article
Description
Skeletal muscle atrophy is a response to decreased physical signals (unloading), such as under microgravity, bed rest and neural inactivation, and is characterized by muscle volume loss and muscle fiber-type switching.
We previously demonstrated that elevated ubiquitin ligase casitas B-lineage lymphoma-b (Cbl-b) resulted in the loss of muscle volume. Here, we showed that the ROS-mediated signal transduction caused by microgravity or its simulation contributes to Cbl-b expression.
In L6 myotubes, the assessment of redox status revealed that oxidized glutathione was increased under microgravity conditions, and simulated microgravity caused a burst of ROS, implicating ROS as a critical upstream mediator linking to downstream atrophic signaling. ROS generation activated the ERK 1/2 early-growth response protein (Egr) 1/2-Cbl-b signaling pathway.
Our results suggest that under microgravity conditions, elevated ROS may be a crucial mechanotransducer in skeletal muscle cells, regulating muscle mass through Cbl-b expression activated by the ERK-Egr signaling pathway.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
75
Issue
1-2
Start Page
11
End Page
16
Sort Key
11
Published Date
2019-04-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences