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ID 114977
Title Alternative
Phenotype Conversion of Salivary Gland Cells
Author
Kurabuchi, Shingo The Nippon Dental University
Chen, Gang Nantong University
Keywords
5α-dihydrotestosterone
epidermal growth factor
granular convoluted tubular cells
mK1
submandibular gland
Content Type
Journal Article
Description
Four major kallikreins (mK1, mK22, mK9, and mK13) were identified in the mouse submandibular gland (SMG). mK1, a true tissue kallikrein, was used as a protein marker to identify different types of SMG granular convoluted tubule (GCT) cells along with epidermal growth factor (EGF), nerve growth factor (NGF), and renin. Kallikrein mK1 was localized in a very small number (~5%) of GCT cells, which were scattered throughout the GCT, indicating that the majority of GCT cells are mK1-negative. Among mK1-positive cells, particularly strong signals were observed in a small number of narrow cells, recognized as slender granular cells (SG cells, Type IV), in the GCT. After postnatal development of the SMG, GCT cells are no longer uniform based on the bioactive substances (mK1, EGF, NGF, and renin) that they produce and secrete. GCT cells were classified into four subtypes, Types I–IV, and it became clear that these subtypes are complicatedly and reversibly converted by the endocrine hormones 5α-dihydrotestosterone (DHT) and triiodothyronine (T3). Duct segments with similar morphology or hormone dependency were recognized in the sublingual and parotid glands. The presence of duct cells with such characteristics is therefore a common feature of the three major salivary glands of rodents.
Journal Title
Acta Histochemica et Cytochemica
ISSN
00445991
13475800
NCID
AA00508022
Publisher
The Japan Society of Histochemistry and Cytochemistry
Volume
52
Issue
4
Start Page
59
End Page
65
Published Date
2019-08-27
Rights
This is an open access article distributed under the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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DOI (Published Version)
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language
eng
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departments
Oral Sciences