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ID 115937
Title Alternative
高血圧患者におけるアンジオテンシン II-レニンフィードバック機構に対するL/N型カルシウムチャネル拮抗薬の影響
Author
Kitani, Mitsuhiro Kagawa Prefectural Shirotori Hospital
Kawano, Kazuhiro Yoshinogawa Medical Center
Taketani, Yoshio Shikoku Medical Center for Children and Adults KAKEN Search Researchers
Keywords
L-/N-type calcium channel blocker
renoprotective effect
suppressing renin-angiotensin system
the ratio of Angiotensin-(1–7)/Angiotensin II
Content Type
Thesis or Dissertation
Description
Objectives. Cilnidipine, an L-/N-type calcium channel blocker (CCB), has unique organ-protective properties due to suppression of hyperactivity in the sympathetic nervous system and renin-angiotensin system (RAS). In this study, we hypothesized that cilnidipine might exert a renoprotective effect by suppressing the RAS.
Methods. A total of 25 hypertensive patients receiving a RAS inhibitor were randomly assigned to a cilnidipine (n = 12) or amlodipine (n = 13) group. The effects of cilnidipine on proteinuria and angiotensin II–renin feedback were assessed.
Results. After 6 months of treatment, both systolic and diastolic blood pressures were significantly reduced to a similar extent in both groups. The urine albumin-to-creatinine ratio was significantly lower in the cilnidipine group (p < 0.05) than in the amlodipine group. Amlodipine increased plasma angiotensin I and angiotensin II levels (p < 0.05), whereas cilnidipine did not. Interestingly, the cilnidipine group had a higher ratio of angiotensin-(1–7) (Ang-(1–7)) to angiotensin II in plasma than the amlodipine group (p < 0.05).
Conclusions. The L-/N-type CCB cilnidipine, but not amlodipine, decreased urinary albumin excretion in hypertensive patients. Cilnidipine also increased the ratio of Ang-(1–7) to angiotensin II in plasma, which might be one factor underlying its beneficial effects.
Journal Title
International Journal of Hypertension
ISSN
20900384
20900392
Publisher
Hindawi
Volume
2020
Start Page
6653851
Published Date
2020-12-22
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Yutaka Kawabataの学位論文として提出され,学位審査・授与の対象となっている。
Rights
Copyright © 2020 Yutaka Kawabata et al.
This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3478号
Diploma Number
甲医第1480号
Granted Date
2021-02-25
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences