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ID 118560
Yanamoto, Souichi Nagasaki University
Michi, Yasuyuki Tokyo Medical and Dental University
Otsuru, Mitsunobu Nagasaki University
Inomata, Toru The Nippon Dental University
Nakayama, Hideki Kumamoto University
Nomura, Takeshi Tokyo Dental College
Hasegawa, Takumi Kobe University
Yamada, Shin-ichi Shinshu University
Kusukawa, Jingo Kurume University
Yamakawa, Nobuhiro Nara Medical University
Hasegawa, On Tokyo Medical University
Ueda, Michihiro National Hospital Organisation Hokkaido Cancer Center
Kitagawa, Yoshimasa Hokkaido University
Hiraki, Akimitsu Fukuoka Dental College
Hasegawa, Toshihiro Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
Ohiro, Yoichi Hokkaido University
Kobayashi, Wataru Hirosaki University
Asoda, Seiji Keio University
Kobayashi, Takanori Nagaoka Red Cross Hospital
Iino, Mitsuyoshi Yamagata University
Fukuda, Masayuki Akita University
Ishibashi-Kanno, Naomi University of Tsukuba
Kawaguchi, Koji Tsurumi University
Aijima, Reona Saga University
Noguchi, Kazuma Hyogo College of Medicine
Okura, Masaya Saiseikai Matsusaka General Hospital
Tanaka, Akira The Nippon Dental University
Sugiura, Tsuyoshi Kagoshima University
Shintani, Yukari Wakayama Medical University
Yagihara, Kazuhiro Saitama Cancer Center
Yamashiro, Masashi NTT Medical Center Tokyo
Ota, Yoshihide Tokai University
Miyazaki, Akihiro Sapporo Medical University
Takeshita, Akinori Osaka University
Kawamata, Hitoshi Dokkyo Medical University
Iwabuchi, Hiroshi Kanagawa Dental University
Uchida, Kenichiro Yamaguchi University
Umeda, Masahiro Nagasaki University
Kurita, Hiroshi Shinshu University
Kirita, Tadaaki Nara Medical University
Content Type
Journal Article
Introduction: In early-stage oral tongue squamous cell carcinoma (OTSCC), elective neck dissection (END) is recommended when occult lymph node metastasis is suspected; however, there is no unanimous consensus on the risks and benefits of END in such cases. The management of clinically node-negative (cN0) OTSCC remains controversial. This study, therefore, aimed to evaluate the efficacy of END and its impact on the quality of life (QoL) of patients with cN0 OTSCC.
Methods and analysis: This is a prospective, multicentre, nonrandomised observational study. The choice of whether to perform END at the same time as resection of the primary tumour is based on institutional policy and patient preference. The primary endpoint of this study is 3-year overall survival. The secondary endpoint are 3-year disease-specific survival, 3-year relapse-free survival and the impact on patient QoL. Propensity score-matching analysis will be performed to reduce selection bias.
Ethics and dissemination: This study was approved by the Clinical Research Review Board of the Nagasaki University. The protocol of this study was registered at the University Hospital Medical Information Network Clinical Trials Registry. The datasets generated during the current study will be available from the corresponding author on reasonable request. The results will be disseminated internationally, through scientific and professional conferences and in peer-reviewed medical journals.
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BMJ Open
BMJ Publishing Group
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著者英表記誤記あり (誤)Iwabuchi Hiroshi→(正)Hiroshi Iwabuchi
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:
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University Hospital