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ID 117019
Title Alternative
YKL-40 is associated with MIA syndrome in HD
Author
Yamada, Kohsuke Kamakura Women’s University|University of Shizuoka
Hyodo, Toru Eijin Clinic
Urabe, Syunichiro Eijin Clinic
Haga, Satomi Eijin Clinic
Hosaka, Toshio University of Shizuoka
Keywords
YKL-40
γ-GTP
hemodialysis
malnutrition
inflammation
Content Type
Journal Article
Description
Chitinase-3-like protein 1 (YKL-40) is a glycoprotein associated with inflammation and tissue remodeling that has recently been used as a marker of inflammation in hemodialysis (HD) patients. In this study, we aimed to determine whether YKL-40 has potential to serve as a nutritional parameter in Japanese HD patients. The serum YKL-40 concentration, hematological parameters, inflammatory marker levels, anthropometric measurements, and laboratory values were measured in 88 patients receiving HD. The geriatric nutritional risk index (GNRI) was used as a nutritional assessment tool. 45.4% of patients were malnourished. YKL-40 correlated positively with age, alkaline phosphatase, alanine transaminase and γ-glutamyl transpeptidase (γ -GTP) levels, but not with nutritional status, and correlated inversely with ankle brachial index score, a predictor of atherosclerosis. Furthermore, multiple regression analysis confirmed that γ-GTP, GNRI and age correlated with YKL-40. YKL-40 elevation was associated with γ-GTP, GNRI and age in HD patients.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
69
Issue
1-2
Start Page
101
End Page
106
Sort Key
101
Published Date
2022-02
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher