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ID 117015
Title Alternative
Biotin levels in blood and follicular fluid
血中および卵胞液中ビオチン濃度と体外受精/顕微授精患者における妊娠転帰との関連について
Author
Yanagihara, Rie Tokushima University
Noguchi, Hiroki Tokushima University
Yano, Yuya Tokushima University
Hayashi, Noriko Tokushima University
Ohta, Chiaki Tokushima University
Kamada, Shuhei Tokushima University
Aoki, Hidenori Tokushima University
Tamura, Kou Tokushima University
Masaki, Rie Tokushima University
Tachibana, Ayaka Tokushima University
Arakaki, Ryosuke Tokushima University
Keywords
biotin
IVF/ICSI
follicular fluid
pregnancy
Content Type
Thesis or Dissertation
Description
It has been shown that biotin, a water-soluble vitamin (B7), plays roles in reproductive functions, such as oocyte maturation and embryo development, in experimental animals. On the other hand, little is known about the clinical effects of biotin on human reproduction. In this study, serum and follicular fluid biotin levels were measured in patients who underwent in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI), and their associations with reproductive outcomes were evaluated. As a result, biotin was detected in follicular fluid, as well as serum, and the biotin levels of follicular fluid were found to be positively correlated with those of serum. The biotin levels of serum were higher than those of follicular fluid, suggesting that biotin may be taken up into the follicular fluid from the blood. Although serum and follicular fluid biotin levels tended to be higher in pregnant patients than in non-pregnant patients, these data did not show the significant statistical difference. These findings indicate that biotin does not contribute to the maintenance of oocyte quality, and hence, it does not increase fertilization and pregnancy rates.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
69
Issue
1-2
Start Page
65
End Page
69
Sort Key
65
Published Date
2022-02
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Rie Yanagiharaの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3792号
Diploma Number
甲医第1596号
Granted Date
2024-03-22
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences